FlyBase Allele Report: Dmel\l(3)S089004[S089302]

General Information

Symbol

Dmel\l(3)S089004^S089302

Species

D. melanogaster

Name

FlyBase ID

FBal0099994

Feature type

allele

Associated gene

l(3)S089004

Associated Insertion(s)

P{lacW}l(3)S089004^S089302

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Deak et al., 1997)

P-element activity

(Szeged Stock Center, 1998-)

Progenitor genotype

Associated Insertion(s)

P{lacW}l(3)S089004^S089302

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Szeged Stock Center, 1998-, Deak et al., 1997)

Phenotype Manifest In

follicle cell (with l(3)S089004^S089004)

(Kuhfittig et al., 2001)

nurse cell & nucleus (with l(3)S089004^S089004)

(Kuhfittig et al., 2001)

oocyte nucleus (with l(3)S089004^S089004)

(Kuhfittig et al., 2001)

Detailed Description

Statement

Reference

The egg cell nucleus develops abnormally in l(3)S089004^S089004/l(3)S089004^S089302 egg chambers. Clumps of condensed chromatin are often seen within nurse cell nuclei. The number of follicle cells is reduced in l(3)S089004^S089004/l(3)S089004^S089302 females. Chimeric females containing l(3)S089004^S089004/l(3)S089004^S089302 pole cells in a l(3)S089004⁺ soma do not lay eggs. Females containing homozygous follicle cell clones produce offspring at a similar rate to control females.

(Kuhfittig et al., 2001)

Early lethal.

(Deak et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

Su(var)3-9^ptn, l(3)S089004^S089302 has follicle cell phenotype

(Kuhfittig et al., 2001)

Su(var)3-9^ptn, l(3)S089004^S089302 has oocyte nucleus phenotype

(Kuhfittig et al., 2001)

Su(var)3-9^ptn, l(3)S089004^S089302 has nurse cell & nucleus phenotype

(Kuhfittig et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The egg cell nucleus develops abnormally in Su(var)3-9^ptn/l(3)S089004^S089302 egg chambers. Clumps of condensed chromatin are often seen within nurse cell nuclei. The arrangement of follicle cells appears abnormal in Su(var)3-9^ptn/l(3)S089004^S089302 females.

(Kuhfittig et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Precise excision of the P{lacW} element reverts the mutant phenotype. FlyBase curator comment: Su(var)3-9^ptn was reported to be allelic to two P-element insertion alleles at 67C (l(3)S089004^S089004 and l(3)S089004^S089302) in FBrf0134644. However, FBrf0180260 demonstrates that Su(var)3-9^ptn is an allele of Su(var)3-9 (at 88E) and that the l(3)S089004^S089004 and l(3)S089004^S089302 alleles at 67C represent a separate "modifier of dominant female sterility" locus. The phenotypes reported for Su(var)3-9^ptn/l(3)S089004^S089004 and Su(var)3-9^ptn/l(3)S089004^S089302 transheterozygotes in FBrf0134644 therefore represent genetic interactions between non-allelic mutations and not a failure to complement between allelic mutations.

(Kuhfittig et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

0893/02

(Deak et al., 1997)

l(3)S089004^S089302

l(3)S089302^S089302

ptn^P893/2

(Kuhfittig et al., 2001)

ptn^S089302

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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