FlyBase Allele Report: Dmel\HnRNP-K[v6]

General Information

Symbol

Dmel\HnRNP-K^v6

Species

D. melanogaster

Name

FlyBase ID

FBal0101494

Feature type

allele

Associated gene

Dmel\HnRNP-K

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Charroux et al., 1999)

Progenitor genotype

HnRNP-K¹⁷⁶

(Charroux et al., 1999)

Cytology

Description

Imprecise excision of the P{lacW} element resulting in a deletion removing the bl transcription unit.

(Charroux et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage (with HnRNP-K^v4)

(Charroux et al., 1999)

lethal (with HnRNP-K^v5)

(Charroux et al., 1999)

lethal | recessive

(Charroux et al., 1999)

partially lethal (with HnRNP-K^v4)

(Charroux et al., 1999)

Phenotype Manifest In

eye

(Charroux et al., 1999)

eye (with HnRNP-K^v4)

(Charroux et al., 1999)

eye (with HnRNP-K^v5)

(Charroux et al., 1999)

leg

(Charroux et al., 1999)

leg (with HnRNP-K^v4)

(Charroux et al., 1999)

leg (with HnRNP-K^v5)

(Charroux et al., 1999)

wing

(Charroux et al., 1999)

wing (with HnRNP-K^v4)

(Charroux et al., 1999)

wing (with HnRNP-K^v5)

(Charroux et al., 1999)

wing disc

(Charroux et al., 1999)

wing disc (with HnRNP-K^v4)

(Charroux et al., 1999)

Detailed Description

Statement

Reference

bl^v4/bl^v6 flies show 10% viability. Homozygous and bl^v5/bl^v6 flies show 1-5% viability. The legs, eyes and wings are smaller than normal in bl^v4/bl^v6 flies; the eyes are nearly wild-type, a weak phenotype is seen in the leg and a strong phenotype is seen in the wing. The legs, eyes and wings are smaller than normal in homozygous and bl^v5/bl^v6 flies; a weak phenotype is seen in the eye (20-25% of flies have smaller eyes than normal) and strong phenotypes are seen in the leg and wing. bl^v4/bl^v6 third larval instar wing discs show no differences in cell death compared to wild-type discs. No obvious differences in cell size compared to wild-type cells are seen in the wing discs. The mutant discs show a significant reduction in BrdU staining compared to wild type. At 29^oC, almost 100% of bl^v4/bl^v6 flies carrying bl^hs.PC die during the second or third larval instar stage.

(Charroux et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

HnRNP-K^v6, Hsap\HNRNPK^hs.PC has partially lethal phenotype

(Charroux et al., 1999)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

51% of bl^v4/bl^v6 flies carrying Hsap\HNRNPK^hs.PC are viable at 25^oC.

(Charroux et al., 1999)

Complementation and Rescue Data

Rescued by

HnRNP-K^v6/HnRNP-K^v4 is rescued by HnRNP-K^hs.PC

(Charroux et al., 1999)

Comments

62% of bl^v4/bl^v6 flies carrying bl^hs.PC are fully viable at 25^oC. The mutant phenotype of these flies is also rescued.

(Charroux et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

HnRNP-K^v6

bl^v6

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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