FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mef2II.UAS
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General Information
Symbol
Dmel\Mef2II.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0101612
Feature type
allele
Associated gene
Dmel\Mef2
Associated Insertion(s)
Carried in Construct
P{UAS-Mef2.II}
Key Links
Transgenic product class
wild_type
(Gunthorpe et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Gunthorpe et al., 1999)
Mutagen
in vitro construct
(Gunthorpe et al., 1999)
Progenitor genotype
Carried in construct
P{UAS-Mef2.II}
Cytology
Description

UAS regulatory sequences drive expression of the type II Mef2 isoform.

(Gunthorpe et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Mef2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Mef2II.Scer\UAS under the control of Scer\GAL4P0.5.Pdf causes long locomotor activity rhythms, with a period of 25.1 +/- 0.1 hours.

      Expression of Mef2II.Scer\UAS under the control of Scer\GAL4tim.Scer\UAS causes long locomotor activity rhythms, with a period of 25.6 +/- 0.3 hours. 47.6% of the flies have a single rhythm, 28.6% of flies have a complex rhythm (classified as more than one rhythmic period detectable above the 95% significance line using Lomb-Scargle analysis of periodograms) and 23.8% are arrhythmic.

      (Blanchard et al., 2010)

      Embryos expressing Mef2II.Scer\UAS under the control of Scer\GAL4da.G32 secrete a cuticle of normal thickness that has denticle belts, although they show patterning defects. No phenotype is produced by the expression of Mef2II.Scer\UAS under the control of Scer\GAL4twi.PB.

      (Gunthorpe et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4how-24B/Mef2II.UAS rescues Mef222-21

      (Gunthorpe et al., 1999)
      Comments

      Partially rescues the phenotypes of Mef222-21 embryos when expressed under the control of Scer\GAL4how-24B at 18oC. At 29oC, the somatic musculature is essentially rescued, although occasional muscles in some hemisegments are missing. Unfused myoblasts are not seen in the embryos at 29oC.

      (Gunthorpe et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mef2II.Scer\UAS
      Mef2II.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)