FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\5-HT2AUAS.cCa
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General Information
Symbol
Dmel\5-HT2AUAS.cCa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Colas
FlyBase ID
FBal0101838
Feature type
allele
Associated gene
Dmel\5-HT2A
Associated Insertion(s)
Carried in Construct
P{UAS-5-HT2A.C}
Key Links
Transgenic product class
cDNA
(Colas et al., 1999)
wild_type
(Colas et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Colas et al., 1999)
wild_type
(Colas et al., 1999)
Mutagen
in vitro construct
(Colas et al., 1999)
Progenitor genotype
Carried in construct
P{UAS-5-HT2A.C}
Cytology
Description

Expression of full length 5-HT2 cDNA is governed by UAS regulatory sequences.

(Colas et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
5-HT2A
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pan-neuronal expression of 5-HT2AScer\UAS.cCa in adult flies (using 31[o]C heat-induced Scer\GAL4nSyb.PS in combination with Scer\GAL80ts.αTub84B) does not significantly affect wall following behavior (posited measure of anxiety) or walking speed in an arena, compared to non-induced (18[o]C) controls.

      (Mohammad et al., 2016)

      Embryos expressing 5-HT2Scer\UAS.cCa under the control of Scer\GAL4Kr.PM show altered cell speed movements during germband extension, with ectodermal cells close to the pole cells showing increased cell speeds compared to equivalent cells in control embryos.

      (Schaerlinger et al., 2007)

      When expression is driven by Scer\GAL4Kr.PM there are initially significant perturbations at the beginning of gastrulation, due to a mistiming in morphogenetic movements, which is compensated later in embryogenesis by an increase in rate of cell movement. Heat shocking increases the lethality.

      (Colas et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      5-HT2Scer\UAS.cCa
      5-HT2AScer\UAS.cCa
      5-HT2AUAS.cCa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Colas
      (Colas et al., 1999)
      Secondary FlyBase IDs
        References (6)