FlyBase Allele Report: Dmel\spen[unspecified]

General Information

Symbol

Dmel\spen^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0102388

Feature type

allele

Associated gene

Dmel\spen

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Therrien et al., 2000)

Phenotype Manifest In

larval longitudinal connective

(Kuang et al., 2000)

Detailed Description

Statement

Reference

In a stage 16 mutant embryo, the longitudinal axon fascicles stall and are misrouted. Axons appear less well fasciculated than in wild-type embryos.

(Kuang et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

spen^unspecified/spen[+] is an enhancer of lethal phenotype of Raf¹²

(Therrien et al., 2000)

spen^unspecified/spen[+] is an enhancer of visible phenotype of ksr::tor^{ΔNksr.hs.sev}

(Therrien et al., 2000)

NOT Enhancer of

Statement

Reference

spen^unspecified/spen[+] is a non-enhancer of visible phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

NOT Suppressor of

Statement

Reference

spen^unspecified/spen[+] is a non-suppressor of visible phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

spen^unspecified has sclerite & embryonic head | ectopic phenotype, enhanceable by Antp^unspecified

(Wiellette et al., 1999)

Enhancer of

Statement

Reference

spen^unspecified/spen[+] is an enhancer of eye phenotype of ksr::tor^{ΔNksr.hs.sev}

(Therrien et al., 2000)

spen^unspecified is an enhancer of denticle belt & embryonic thoracic segment phenotype of tsh^unspecified

(Wiellette et al., 1999)

spen^unspecified is an enhancer of denticle belt & embryonic abdominal segment 1 phenotype of tsh^unspecified

(Wiellette et al., 1999)

spen^unspecified is an enhancer of sclerite & embryonic mesothoracic segment | ectopic phenotype of Antp^unspecified

(Wiellette et al., 1999)

NOT Enhancer of

Statement

Reference

spen^unspecified/spen[+] is a non-enhancer of eye phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

NOT Suppressor of

Statement

Reference

spen^unspecified/spen[+] is a non-suppressor of eye phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

Other

Statement

Reference

spen^unspecified, tsh^unspecified has denticle belt & embryonic thoracic segment phenotype

(Wiellette et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Embryos mutant for spen and Antp show more sclerotic material in dorsal T2 than do Antp mutants alone and the ectopic head sclerites are more sclerotinised than in spen mutants alone. In tsh mutants the T1 denticle belt is absent and the denticles themselves are smaller and more disorganised than wild type. When also mutant for spen the denticle belts are missing from all thoracic segments, and the A1 denticle belt is poorly defined.

(Wiellette et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

spen^P1

(Kuang et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

spen^unspecified

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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