FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ApplsdΔCg.UAS
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General Information
Symbol
Dmel\ApplsdΔCg.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0103096
Feature type
allele
Associated gene
Dmel\Appl
Associated Insertion(s)
Carried in Construct
P{UAS-Appl.sdΔCg}
Key Links
Transgenic product class
inframe_deletion
(Torroja et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Torroja et al., 1999)
Mutagen
in vitro construct
(Torroja et al., 1999)
Progenitor genotype
ApplUAS.cTa
(Torroja et al., 1999)
Carried in construct
P{UAS-Appl.sdΔCg}
Cytology
Description

Deletion of the cleavage site (therefore protein tethered to membrane) and Gobinding domain (amino acids 845-855) of the Appl coding region.

(Torroja et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Appl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing ApplsdΔCg.UAS under the control of Scer\GAL4GMR91H05 leads to retraction of adult giant fiber terminals.

      (Penserga et al., 2019)

      When expression is driven in the motoneurons muscles 6 and 7 (abdominal segment 3) total number of synaptic boutons is increased, percentage of satellite boutons is increased and the number of normal boutons is unchanged.

      (Torroja et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ApplsdΔCg.Scer\UAS
      ApplsdΔCg.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)