FB2026_03 , released September 17, 2026
Allele: Dmel\perΔC2
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General Information
Symbol
Dmel\perΔC2
Species
D. melanogaster
Name
FlyBase ID
FBal0103630
Feature type
allele
Associated gene
Dmel\per
Associated Insertion(s)
Carried in Construct
P{perΔC2}
Key Links
Transgenic product class
inframe_deletion
(Schotland et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Schotland et al., 2000)
Mutagen
in vitro construct
(Schotland et al., 2000)
Progenitor genotype
per+t12.3
(Schotland et al., 2000)
Carried in construct
P{perΔC2}
Cytology
Description

A 159bp in-frame deletion which removes sequences encoding per amino acids 515 to 568, including 11 Ser and Thr residues.

(Schotland et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
per
Encoded product / tool
per
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying perΔC2 in a wild-type background show no affect on temperature compensation of circadian period, but have a shorter period of locomotor activity than wild type. Flies carrying per+t12.3 have a phase response curve (PRC) that would be predicted for flies with 27 hour locomotor activity periods at 27oC. Flies carrying perΔC2 have a very different PRC despite the similarity of their periods at this temperature. In flies carrying perΔC2, delays do not occur until ZT17 and advances do not occur at all at the times predicted by the per+t12.3 PRC.

      (Schotland et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      perΔC2 partially rescues per01

      (Schotland et al., 2000)
      Comments

      perΔC2 rescues rhythmicity of free running locomotor activity in per01 flies at 25oC, but the rhythms have a shorter period than those produced by the control (per+t12.3 in a per01 background). per01 flies carrying perΔC2 show an increase in period of as much as 5 hours when moved from 20 to 27oC, compared with a 0.9 hour increase in wild-type flies.

      (Schotland et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      perΔC2
      Name Synonyms
      Secondary FlyBase IDs
        References (1)