FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.
wing & cell | somatic clone
Cells in homozygous somatic clones at the wing margin are reduced compared to their neighbours. In somatic clones in the eye, homozygous mutant photoreceptor and pigment cells are also reduced in size. In both cases the reduced cell size is cell autonomous.
Expression of RetMEN2B.Scer\UAS enhances the "distant seeding" phenotype seen when Nek2Scer\UAS.T:Avic\GFP is expressed under the control of Scer\GAL4GMR.PF. Larger groups of Avic\GFP-positive cells are detected in distant body parts. This phenotype is significantly reduced when flies also carry one copy each of Pi3K21Bunspecified and S6kunspecified. The phenotype can also be suppressed by drugs that inhibit signalling along the PI3K cascade; LY294002, Rapamycin, MK2206 or BEZ235.
One copy of S6kunspecified suppresses the lethality seen when flies expressing RetMEN2B.Scer\UAS under the control of Scer\GAL4ptc-559.1 are fed AD58.
