FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HDAC1328
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General Information
Symbol
Dmel\HDAC1328
Species
D. melanogaster
Name
FlyBase ID
FBal0104001
Feature type
allele
Associated gene
Dmel\HDAC1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Mottus et al., 2000)
Mutagen
ethyl methanesulfonate
(Sinclair et al., 1983)
Progenitor genotype
Cytology
Description

The mutated residue C98 is perfectly conserved in homologs from S. cerevisiae to H. sapiens, in a region of the protein that is almost perfectly conserved, and that is thought to be required for deacetylase activity. Lesions in HDAC1303 and HDAC1328, which were independently isolated, are identical.

(Mottus et al., 2000)

Amino acid replacement: C98Y.

(Mottus et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:4,627,747..4,627,747 [+]
Nucleotide change:

G4627747A

Amino acid change:

C98Y | HDAC1-PA

Reported amino acid change:

C98Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Mottus et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Schimke immuno-osseous dysplasia
      modeled by Marcal1UAS.cBa
      (Morimoto et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Strong suppressor of PEV in In(1)wm4. Raises the pigment levels of In(1)wm4 eyes from 5-15% of wild type levels to 60-90% of wild type levels. Significant suppressor of PEV in T(2;3)SbV. Significant suppressor of PEV in In(2R)bwVDe2 in females. In males the effect is slight, being, if anything, an enhancement of the PEV. Some adult male flies of the genotype Rpd304556/Rpd3328 do eclose but survive only a few days. They show very strong suppression of PEV. Recessive lethality acts equally in the third larval instar or during pupation. Shows a dominant semi-lethal effect on males: viability 78% of expected.

      (Mottus et al., 2000)

      Dominant suppressor of position effect variegation in eye pigment caused by In(1)wm4 or In(2R)bwVDe2. Dominant suppressor of position effect variegation at the Sb locus caused by T(2;3)SbV. The suppressor effect on the variegation caused by In(1)wm4 is substantially reduced or eliminated entirely in male XO flies lacking a Y chromosome. The suppressor effect is also reduced by maintaining flies at 29oC. Rpd3326/Rpd3328 heterozygotes are inviable, suggesting the two mutations are allelic.

      (Sinclair et al., 1983)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially complements

      HDAC115-1

      (Mottus et al., 2000)
      Fails to complement

      HDAC1303

      (Mottus et al., 2000)

      HDAC1313

      (Mottus et al., 2000)

      HDAC104556

      (Mottus et al., 2000)

      HDAC1326

      (Mottus et al., 2000)
      Comments

      Transheterozygotes of Rpd315-1 with Rpd3303, Rpd3313, Rpd3326 or Rpd3328 are viable and fertile, and show weak to moderate suppression of In(1)wm4 PEV.

      (Mottus et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      HDAC1328
      (Mottus et al., 2000)
      Rpd3328
      (Bhaskar et al., 2014)
      Su(var)328unspecified
      unspecified
      (Sinclair et al., 1983)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)