FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\BobAUAS.cLa
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General Information
Symbol
Dmel\BobAUAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Lai
FlyBase ID
FBal0104352
Feature type
allele
Associated gene
Dmel\BobA
Associated Insertion(s)
Carried in Construct
P{UAS-BobA.L}
Key Links
Transgenic product class
cDNA
(Posakony, 2000.2.8)
wild_type
(Posakony, 2000.2.8)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Posakony, 2000.2.8)
wild_type
(Posakony, 2000.2.8)
Mutagen
in vitro construct
(Lai et al., 2000, Posakony, 2000.2.8)
Progenitor genotype
Carried in construct
P{UAS-BobA.L}
Cytology
Description

UASt regulatory sequences drive expression of the coding region and a few nucleotides of 5' UTR sequence (to provide translational initiation context) of BobA.

(Lai et al., 2000)

UASt regulatory sequences drive expression of a BobA cDNA.

(Posakony, 2000.2.8)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
BobA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing BobAScer\UAS.cLa under the control of Scer\GAL4sca-537.4 show defects in the adult peripheral nervous system, having a strong tufting or lethal phenotype, with bristle tufting extending to most macrochaetae and microchaetae, as well as occasional bristle loss. Supernumerary sensory organ precursor cells are seen in wing imaginal discs of animals expressing BobAScer\UAS.cLa under the control of Scer\GAL4sca-537.4. Expression of BobAScer\UAS.cLa under the control of either Scer\GAL4Bx-MS1096 or Scer\GAL469B does not appear to alter wing vein fates or the overall integrity of the wing margin, although sensory organ fates in each of these territories are altered. Expression of BobAScer\UAS.cLa under the control of Scer\GAL4sca-109-68 occasionally results in a "double shaft" phenotype in which two bristle shafts are present at the expense of the socket cell.

      (Lai et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The nucleotide sequence of the BobA clone used to make this construct has a one base conservative substitution difference from the nucleotide sequence of BobB and BobC. The predicted "Bob" protein produced by this construct is identical to that of BobA, BobB and BobC.

      (Posakony, 2000.2.8)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      BobAScer\UAS.cLa
      BobAUAS.cLa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Lai
      (Lai et al., 2000)
      Secondary FlyBase IDs
        References (3)