FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ubx::HrobLox2UAS.cCa
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General Information
Symbol
Dmel\Ubx::Hrob\Lox2UAS.cCa
Species
D. melanogaster
Name
FlyBase ID
FBal0104698
Feature type
allele
Associated gene
Ubx::Hrob\Lox2
Associated Insertion(s)
Carried in Construct
P{UAS-Ubx1a::Lox2HD.G}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Grenier and Carroll, 2000)
Progenitor genotype
UbxUAS.cCa
(Grenier and Carroll, 2000)
Carried in construct
P{UAS-Ubx1a::Lox2HD.G}
Cytology
Description

The homeodomain of Ubx has been replaced by the homeodomain from Hrob\Lox2. This leads to changes in 15 amino acids.

(Grenier and Carroll, 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Ubx::Hrob\Lox2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of Ubx::Hrob\Lox2Scer\UAS.cCa driven by Scer\GAL4dpp.blk1 causes transformation of the antenna towards a thoracic leg. Overexpression of Ubx::Hrob\Lox2Scer\UAS.cCa driven by Scer\GAL4Bx-MS1096 causes transformation of the wing towards a haltere. This transformation is more severe in males than in females. The phenotype is stronger on the dorsal surface of the wing. Overexpression of Ubx::Hrob\Lox2Scer\UAS.cCa in the ectoderm, driven by Scer\GAL4arm.PS, transforms the denticle belts of thoracic segments towards A1 identity. The development of Keilin's organs and ventral pits are repressed.

      (Grenier and Carroll, 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ubx::Hrob\Lox2Scer\UAS.cCa
      Ubx::Hrob\Lox2UAS.cCa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)