FlyBase Allele Report: Mmus\Emx2[hs.PH]

General Information

Symbol

Mmus\Emx2^hs.PH

Species

M. musculus

Name

heat shock construct of Hartmann

FlyBase ID

FBal0104753

Feature type

allele

Associated gene

Mmus\Emx2

Associated Insertion(s)

Carried in Construct

P{hs-Emx2}

Transgenic product class

cDNA

(Hartmann et al., 2000)

wild_type

(Hartmann et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Hartmann et al., 2000)

wild_type

(Hartmann et al., 2000)

Mutagen

in vitro construct

(Hartmann et al., 2000)

Progenitor genotype

Carried in construct

P{hs-Emx2}

Cytology

Description

Construct: A 2.2kb Mmus\Emx2 cDNA fragment is driven by a heatshock promoter.

(Hartmann et al., 2000)

Allele components

Component

Use(s)

Encoded product / tool

Mmus\Emx2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Mmus\Emx2^hs.PH is a suppressor of abnormal neuroanatomy phenotype of ems²

(Hartmann et al., 2000)

Phenotype Manifest In

Suppressor of

Statement

Reference

Mmus\Emx2^hs.PH is a suppressor of larval ventral nerve cord phenotype of ems²

(Hartmann et al., 2000)

Mmus\Emx2^hs.PH is a suppressor of larval longitudinal connective phenotype of ems²

(Hartmann et al., 2000)

NOT Suppressor of

Statement

Reference

Mmus\Emx2^hs.PH is a non-suppressor of larval ventral nerve cord commissure phenotype of ems²

(Hartmann et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Heatshocked induced ubiquitous expression of Mmus\Emx2^hs.PH in ems² null mutants leads to substantial restoration of brain morphology. In a quarter of cases the cellular gap and the longitudinal ganglion are restored, However projection defects are not rescued. Overexpression in ems mutants perturb axiogenesis in the ventral nerve cord (VNC), the axon scaffold was deranged in these animals, and in many cases the anterior and posterior commissures are fused and the longitudinal connectives are disrupted. Also supernumerary eve expressing cells are seen in the VNC.

(Hartmann et al., 2000)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Mmus\Emx2^hs.PH

Name Synonyms

heat shock construct of Hartmann

(Hartmann et al., 2000)

Secondary FlyBase IDs

References (1)

Report Sections

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