FlyBase Allele Report: Dmel\pros[V78]

General Information

Symbol

Dmel\pros^V78

Species

D. melanogaster

Name

FlyBase ID

FBal0105089

Feature type

allele

Associated gene

Dmel\pros

Associated Insertion(s)

P{GawB-Δ78.G}pros^V78

Carried in Construct

Also Known As

Voila⁷⁸

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Grosjean et al., 2001, Balakireva et al., 2000)

Progenitor genotype

pros^V1

(Grosjean et al., 2001, Balakireva et al., 2000)

Associated Insertion(s)

P{GawB-Δ78.G}pros^V78

Cytology

Description

Imprecise excision of the P{GawB} element. Scer\GAL4 sequences are still present. w sequences are still present but the size of the w fragment is altered compared to pros^V1. A 2.9kb BamHI-PstI fragment ("pBSK") from the 3' end of the element appears to be intact. Surrounding genomic sequences are unaffected.

(Grosjean et al., 2001)

Imprecise excision of the P{GAL4} element.

(Balakireva et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

carbon dioxide sensitive neuron | ectopic | somatic clone

(Hartl et al., 2011)

Detailed Description

Statement

Reference

Homozygous clones induced by the eyFLP method result in ectopic CO[[2]] neurons on the maxillary palp (MP). The ectopic neurons show dual targeting specificity: in addition to targeting the V-glomerulus they also innervate a set of medial glomeruli normally innervated by two MP olfactory receptor neuron classes. The number of antennal CO[[2]] neurons is unaffected.

(Hartl et al., 2011)

The median lifespan for pros^V78 animals (the age after egg laying at which 50% of homozygotes have died) is 1.67 days at 25^oC.

Homozygous third instar larvae show reduced locomotor activity compared to controls.

Homozygous second instar larvae are indifferent to 0.1M sucrose in a taste response assay, in contrast to wild-type larvae which are significantly attracted by sucrose. They are repulsed by 0.3M NaCl (as are wild-type larvae).

(Grosjean et al., 2003)

The courtship index of heterozygous males towards decapitated Canton-S males is significantly higher than that of wild-type males towards decapitated Canton-S males. The courtship index of heterozygous males towards decapitated Canton-S males is not significantly different from that of heterozygous pros^V1 males towards decapitated Canton-S males. Homozygotes die mostly during the larval stage.

(Grosjean et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Voila⁷⁸

(Grosjean et al., 2001, Balakireva et al., 2000)

pros^V78

(Grosjean et al., 2003)

pros^voila78

(Hartl et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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