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General Information
Symbol
Dmel\HemUAS.cHa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Hummel
FlyBase ID
FBal0105153
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Kette
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A full length Hem cDNA is expressed under the control of UASt regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Overexpression of HemScer\UAS.cHa under the control of Scer\GAL4elav-C155 does not result in any defects in the overall morphology of the embryonic nervous system.

Muscle development in HemScer\UAS.cHa; Scer\GAL4twi.PG embryos appears normal.

Embryos expressing HemScer\UAS.cHa under the control of Scer\GAL4sim.PS in a wild-type background show an abnormal axonal projection phenotype of the VUM neurons.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Phenotype Manifest In
Suppressor of
NOT Suppressor of
Statement
Reference

HemUAS.cHa, Scer\GAL4elav-C155 is a non-suppressor of neuromuscular junction & synapse phenotype of Fmr1EP3517, Scer\GAL4elav-C155

Additional Comments
Genetic Interactions
Statement
Reference

The reduced synaptic length seen at the neuromuscular junction in larvae expressing Fmr1EP3517 under the control of Scer\GAL4elav-C155 is not suppressed by co-expression of HemScer\UAS.cHa.

HemScer\UAS.cHa; Scer\GAL4twi.PG partially suppresses the loss of muscle fusion seen in blow2 homozygous embryos. The resulting embryos form fused and attached muscles, although defects in muscle number, size and attachment occur.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The reduced synaptic length seen at the neuromuscular junction of HemJ1-70/HemΔ2-6 larvae is rescued by expression of HemScer\UAS.cHa under the control of Scer\GAL4elav-C155.

The loss of muscle fusion seen in HemJ4-48 mutant embryos is almost completely rescued by HemScer\UAS.cHa; Scer\GAL4twi.PG.

Fails to rescue the fused commissure phenotype of Hemunspecified embryos when expressed under the control of Scer\GAL4sli.PS. HemScer\UAS.cHa partially rescues the HemJ4-48 phenotype when expressed under the control of Scer\GAL4sim.PS; commissures are separated and connectives are at a further distance from the midline compared to non-rescued HemJ4-48 embryos. The VUM neurons show a normal projection pattern.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
HemScer\UAS.cHa
HemUAS.cHa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Hummel
Secondary FlyBase IDs
    References (4)