FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cdk7nanos-D137R.bcd3'UTR
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General Information
Symbol
Dmel\Cdk7nanos-D137R.bcd3'UTR
Species
D. melanogaster
Name
FlyBase ID
FBal0105262
Feature type
allele
Associated gene
Dmel\Cdk7
Associated Insertion(s)
Carried in Construct
P{nanos-Cdk7.D137R.bcd3'UTR}
Key Links
Transgenic product class
missense_variant
(Leclerc et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Leclerc et al., 2000)
Mutagen
in vitro construct
(Leclerc et al., 2000)
Progenitor genotype
Carried in construct
P{nanos-Cdk7.D137R.bcd3'UTR}
Cytology
Description

Construct: Amino acid replacement: D137R. The mutated Cdk7 cDNA is driven by the nos promoter and is tagged with the bcd 3'UTR.

(Leclerc et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
nanos
Encoded product / tool
Cdk7
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When Cdk7nos-D137R.bcd3'UTR is expressed in early embryos, no modification or delay is seen in the timing of the first 13 nuclear divisions, however at the end of the maternal division program, a corresponding zone with twice the normal density of interphase 14 nuclei are observed, resulting from the appearance of an extra synchronous division in the domain of expression of the Cdk7D137R.Scer\UAS.T:Ivir\HA1 proteins.

      (Leclerc et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Cdk7DN
      (Leclerc et al., 2000)
      Cdk7nanos-D137R.bcd3'UTR
      Cdk7nos-D137R.bcd3'UTR
      Name Synonyms
      Secondary FlyBase IDs
        References (2)