FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cdk21
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General Information
Symbol
Dmel\Cdk21
Species
D. melanogaster
Name
FlyBase ID
FBal0117573
Feature type
allele
Associated gene
Dmel\Cdk2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lane et al., 2000)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygous embryos appear to have wild-type morphology. They incorporate BrdU with normal efficiency and in normal patterns throughout embryogenesis. Hatching of larvae occurs at the same rate as that of control embryos. cdc2c1/cdc2c3 larvae survive for at least 4 days after egg deposition, but their size fails to increase significantly after 1.5 days (in contrast to wild-type larvae).

      (Lane et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      cdc2c[+]/Cdk21 is a suppressor of visible | dominant phenotype of Snr1E1

      (Zraly et al., 2004)

      cdc2c[+]/Cdk21 is a suppressor of visible phenotype of CycEI.hs.2sev

      (Lane et al., 2000)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      cdc2c[+]/Cdk21 is a suppressor of wing vein | ectopic phenotype of Snr1E1

      (Zraly et al., 2004)

      cdc2c[+]/Cdk21 is a suppressor of wing phenotype of Snr1E1

      (Zraly et al., 2004)

      cdc2c[+]/Cdk21 is a suppressor of eye phenotype of CycEI.hs.2sev

      (Lane et al., 2000)

      cdc2c[+]/Cdk21 is a suppressor of ommatidium phenotype of CycEI.hs.2sev

      (Lane et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      At 29oC, cdc2c1/+ suppresses the ectopic wing vein phenotype of Snr1E1/+; 15% of flies have an ectopic vein emanating from the posterior crossvein and 85% have wild-type wings.

      (Zraly et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Cdk22/Cdk21 is rescued by Cdk2hs.PS

      (Lane et al., 2000)

      Cdk22/Cdk21 is rescued by Cdk2AF.hs

      (Lane et al., 2000)

      Cdk21/Df(3R)H81 is rescued by Cdk2+t10

      (Lane et al., 2000)
      Comments

      cdc2c1/cdc2c2 females that have been rescued by periodic expression of cdc2chs.PS readily lay eggs as long as they are subjected to periodic heat shocks (to induce expression of cdc2chs.PS). However, after termination of periodic heat shocks, egg deposition decreases rapidly and stops completely within 2-3 days. This arrest of egg deposition can be readily reversed within 7 days after resumption of periodic heat shocks. Eggs collected from females 1 day after termination of periodic heat shocks often show abnormal spatial distribution of nuclei and the chromatin often appears abnormal. A significant fraction of embryos contain very few nuclei. A significant fraction of embryos contain very few nuclei. About two-thirds of eggs with less than 5 nuclei are not fertilised.

      (Lane et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a dominant modifier of the CycEI.hs.2sev rough eye phenotype.

      (Lane et al., 2000)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cdk21
      (Lane et al., 2000)
      cdc2c1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)