FlyBase Allele Report: Dmel\fz::fz2[2-1-1.UAS.Tag:MYC]

General Information

Symbol

Dmel\fz::fz2^{2-1-1.UAS.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0118222

Feature type

allele

Associated gene

fz::fz2

Associated Insertion(s)

Carried in Construct

P{UAS-fz2-1}

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Boutros et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-fz2-1}

Cytology

Description

UAS sequences drive a cDNA that consists of the CRD domain of fz2 and the transmembrane and C terminal domains of fz. This has been tagged with Tag:MYC in the non-conserved region in between the CRD and the transmembrane domains.

(Boutros et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

fz::fz2

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity, with Scer\GAL4^ap-md544

(Boutros et al., 2000)

abnormal planar polarity, with Scer\GAL4^hs.2sev

(Boutros et al., 2000)

abnormal planar polarity | cell non-autonomous, with Scer\GAL4^dpp.blk1

(Wu et al., 2004)

lethal - all die before end of pupal stage, with Scer\GAL4^Dll-md23

(Boutros et al., 2000)

some die during pupal stage, with Scer\GAL4^Dll-md23

(Boutros et al., 2000)

Phenotype Manifest In

leg | distal, with Scer\GAL4^Dll-md23

(Boutros et al., 2000)

mesonotum, with Scer\GAL4^ap-md544

(Boutros et al., 2000)

ommatidium, with Scer\GAL4^hs.2sev

(Boutros et al., 2000)

wing, with Scer\GAL4^ap-md544

(Boutros et al., 2000)

wing hair | cell non-autonomous, with Scer\GAL4^dpp.blk1

(Wu et al., 2004)

wing margin, with Scer\GAL4^ap-md544

(Boutros et al., 2000)

wing margin, with Scer\GAL4^en-e16E

(Wu et al., 2004)

Detailed Description

Statement

Reference

Expression of fz::fz2^{2-1-1.Scer\UAS.T:Hsap\MYC} in a stripe along the antero-posterior wing compartment boundary using Scer\GAL4^dpp.blk1 is unable to induce non-autonomous effects on the orientation of the adult wing hairs of neighbouring wild-type cells.

(Wu and Mlodzik, 2008)

When fz::fz2^{2-1-1.Scer\UAS.T:Hsap\MYC} is expressed by Scer\GAL4^dpp.blk1, most wing hairs flanking the expression domain point away from it. When fz::fz2^{2-1-1.Scer\UAS.T:Hsap\MYC} is driven by Scer\GAL4^en-e16E large nicks are always seen in the wing margin.

(Wu et al., 2004)

Expression of fz::fz2^{2-1-1.Scer\UAS.T:Hsap\MYC} driven by Scer\GAL4^ap-md544 leads to a variable partial loss the wing margin. Expression of fz::fz2^{2-1-1.Scer\UAS.T:Hsap\MYC} driven by Scer\GAL4^Dll-md23 leads to pupal lethality and loss of distal leg structures.

(Boutros et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

fz::fz2^{2-1-1.Scer\UAS.T:Hsap\MYC}

fz::fz2^{2-1-1.UAS.Tag:MYC}

fz::fz2^{2-1.Scer\UAS.T:Hsap\MYC}

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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