FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\crcE98
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General Information
Symbol
Dmel\crcE98
Species
D. melanogaster
Name
FlyBase ID
FBal0118287
Feature type
allele
Associated gene
Dmel\crc
Associated Insertion(s)
P{?GawB}crcE98
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Hewes et al., 2000)
Progenitor genotype
P{GawB}crc929
(Hewes et al., 2000)
Associated Insertion(s)
P{?GawB}crcE98
Caused by aberration
Df(2L)crcE98
Cytology
Description

Imprecise excision of the P{GawB} element, resulting in a deletion of crc sequences. This mutation disrupts crc isoforms A and D. Some or all of the P{GawB} element remains.

(Hewes et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Lethal phase is primarily after pupariation. Larvae with multiple mouthparts are not seen and puparia are normal in size and shape. Gas bubble translocation, expulsion of the larval tracheae and mouthparts and head eversion are all completed successfully. The distal portion of the everted leg discs often darken abnormally and do not differentiate further. After pupation, the abdomen shrinks markedly and withdraws to a dorsal position in these animals. Subsequently, the head collapses partially or completely into the thoracic cavity. Despite this "head/abdomen-collapsed" phenotype, many pupae develop eye pigmentation and other signs of adult differentiation. crcE98 shows the "head/abdomen-collapsed" phenotype when heterozygous over some second chromosome balancers, suggesting haploinsufficiency for crc in some genetic backgrounds.

      (Hewes et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      crc1

      (Hewes et al., 2000)
      Fails to complement

      crcR6

      (Hewes et al., 2000)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      E98
      (Hewes et al., 2000)
      crcE98
      Name Synonyms
      Secondary FlyBase IDs
        References (1)