FlyBase Allele Report: Dmel\GstE1[EP2231]

General Information

Symbol

Dmel\GstE1^EP2231

Species

D. melanogaster

Name

FlyBase ID

FBal0118450

Feature type

allele

Associated gene

Dmel\GstE1

Associated Insertion(s)

P{EP}GstE1^EP2231

Carried in Construct

Also Known As

EP(2)2231

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-, Fernandez-Funez et al., 2000, Singh et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}GstE1^EP2231

Cytology

Description

The P{EP} insertion is 78bp upstream of the putative ATG start codon in the same orientation to the transcription unit.

(Fernandez-Funez et al., 2000)

P{EP} insertion in GstE1.

(Singh et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:18,398,359..18,398,359 [+]

(Gene Disruption Project members, 2001-, Fernandez-Funez et al., 2000, Singh et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^82Q.UAS

(Fernandez-Funez et al., 2000)

modeled by Hsap\ATXN1^30Q.UAS

(Fernandez-Funez et al., 2000)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of GstE1^EP2231 under the control of Scer\GAL4^GMR.PF does not result in a rough eye phenotype.

(Shulman and Feany, 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

GstE1^EP2231, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

GstE1^EP2231/Scer\GAL4^Act.PU is a suppressor | partially of partially lethal - majority die | recessive phenotype of Sms^e00382

(Li et al., 2017)

GstE1^EP2231/Scer\GAL4^Act.PU is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Sms^e00382

(Li et al., 2017)

GstE1^EP2231/Scer\GAL4^Act.PU is a suppressor of short lived phenotype of Sms^e00382

(Li et al., 2017)

GstE1^EP2231/Scer\GAL4^Act.PU is a suppressor of abnormal neurophysiology | adult stage | progressive phenotype of Sms^e00382

(Li et al., 2017)

GstE1^EP2231/Scer\GAL4^Act.PU is a suppressor of abnormal eye color | adult stage | progressive phenotype of Sms^e00382

(Li et al., 2017)

NOT Suppressor of

Statement

Reference

GstE1^EP2231, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

GstE1^EP2231, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

GstE1^EP2231, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

GstE1^EP2231, Scer\GAL4^GMR.PF is a suppressor of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

NOT Suppressor of

Statement

Reference

GstE1^EP2231, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Other

Statement

Reference

GstE1^EP2231, Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF has ommatidium phenotype

(Fernandez-Funez et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The short lived phenotype of Sms^e00382 homozygotes is strongly suppressed by the expression of GstE1^EP2231 under the control of Scer\GAL4^Act.PU; the partial lethality, adult locomotor defects, progressive eye pigmentation loss and progressive decreases of photoreceptor depolarization and synaptic response (ON and OFF transients) observed in these mutants are also, although more modestly, ameliorated by the expression of GstE1^EP2231.

(Li et al., 2017)

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is not modified if the flies are also carrying GstE1^EP2231.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

The site of the P{EP} insertion is the same in GstE1^EP2230 and GstE1^EP2231.

(Singh et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

EP(2)2231

(Shulman and Feany, 2003, Singh et al., 2000)

Gst3^EP2231

(Fernandez-Funez et al., 2000)

GstE1^EP2231

(Li et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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