FB2026_02 , released June 18, 2026
Allele: Dmel\CycBdbm.UAS.Tag:MYC
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General Information
Symbol
Dmel\CycBdbm.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0118584
Feature type
allele
Associated gene
Dmel\CycB
Associated Insertion(s)
Carried in Construct
P{UAS-CycB-dbm}
Also Known As
UAS-CycB-dbm
Key Links
Transgenic product class
inframe_deletion
(Leismann et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Leismann et al., 2000)
Mutagen
in vitro construct
(Jacobs et al., 2001, Leismann et al., 2000)
Progenitor genotype
Carried in construct
P{UAS-CycB-dbm}
Cytology
Description

UASt sequences drive expression of a mutated CycB, where the destruction box has been replaced by a Tag:MYC tag. The amino acids GT and RT have also been added as a consequence of the cloning strategy and flank the inserted sequence.

(Leismann et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
CycB
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CycBdbm.Scer\UAS when driven by Scer\GAL4prd.RG1, delays progression through mitosis in mutant embryos. There is an enrichment of mitotic figures in which sister chromatids are separated but not segregated all the way to the spindle poles. In 20% of mutant embryos, all cells become arrested in mitosis. This occurs after sister chromatid separation and an initial segregation phase. However sister chromatids do not reach the poles completely and continue to move around individually and often backwards to the central region of arrested cells.

      (Jacobs et al., 2001)

      Expression of CycBdbm.Scer\UAS driven by Scer\GAL4prd.RG1 blocks exit from mitosis in the developing embryo and causes an enrichment of mitotic figures.

      (Leismann et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CycBdbm.Scer\UAS
      CycBdbm.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)