FlyBase Allele Report: Dmel\ttk[69.UAS.Tag:HA]

General Information

Symbol

Dmel\ttk^{69.UAS.Tag:HA}

Species

D. melanogaster

Name

FlyBase ID

FBal0119096

Feature type

allele

Associated gene

Dmel\ttk

Associated Insertion(s)

Carried in Construct

P{UAS-ttk.69}

Key Links

Transgenic product class

wild_type

(Wen et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Wen et al., 2000)

Mutagen

in vitro construct

(Wen et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-ttk.69}

Cytology

Description

UASt regulatory sequences drive expression of the full length ttk69 protein, tagged at the N-terminal end with three copies of Tag:HA.

(Wen et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

ttk

Tagged with

Tag:HA

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^ey.PH

(Wen et al., 2000)

visible, with Scer\GAL4^hs.2sev

(Wen et al., 2000)

Phenotype Manifest In

cone cell | increased number, with Scer\GAL4^hs.2sev

(Wen et al., 2000)

eye, with Scer\GAL4^ey.PH

(Wen et al., 2000)

eye, with Scer\GAL4^hs.2sev

(Wen et al., 2000)

eye photoreceptor cell, with Scer\GAL4^hs.2sev

(Wen et al., 2000)

interommatidial bristle, with Scer\GAL4^hs.2sev

(Wen et al., 2000)

ommatidium, with Scer\GAL4^hs.2sev

(Wen et al., 2000)

photoreceptor cell R7, with Scer\GAL4^hs.2sev

(Wen et al., 2000)

Detailed Description

Statement

Reference

Expression of ttk^{69.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hs.2sev results in a failure of photoreceptor cell differentiation and ectopic cone cell differentiation. Ommatidia with three to five photoreceptor cells are seen in pupal eye discs. The anterior and posterior cone cell precursors are not recruited into the ommatidial clusters in the mutant eye disc. However, the polar and equatorial cone cells are occasionally recruited. The ommatidia contain two to five cone cells. The adult eye appears rough and retinal bristles are abnormally patterned. The ommatidia never contain more than four outer photoreceptor cells and 43% of the ommatidia are missing the R7 cell. Increased spacing between the ommatidia, and some ommatidia lacking all photoreceptor cells is also seen. Expression of ttk^{69.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ey.PH effectively blocks eye formation.

(Wen et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^hs.2sev, ttk^{69.UAS.Tag:HA} has eye phenotype, enhanceable by CtBP[+]/CtBP^87De-10

(Wen et al., 2000)

NOT suppressed by

Statement

Reference

Scer\GAL4^hs.2sev, ttk^{69.UAS.Tag:HA} has eye phenotype, non-suppressible by HDAC1⁰⁴⁵⁵⁶/Rpd3[+]

(Wen et al., 2000)

Scer\GAL4^hs.2sev, ttk^{69.UAS.Tag:HA} has eye phenotype, non-suppressible by Sin3A⁰⁸²⁶⁹

(Wen et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The eye phenotype caused by expression of ttk^{69.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hs.2sev is not dramatically modulated by Sin3A⁰⁸²⁶⁹ or Rpd3⁰⁴⁵⁵⁶. Some of the eye phenotypes caused by expression of ttk^{69.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hs.2sev are enhanced by one copy of CtBP^87De-10.

(Wen et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ttk^{69.Scer\UAS.T:Ivir\HA1}

ttk^{69.UAS.Tag:HA}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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