FlyBase Allele Report: Dmel\UbcE2H[EP1303]

General Information

Symbol

Dmel\UbcE2H^EP1303

Species

D. melanogaster

Name

FlyBase ID

FBal0119370

Feature type

allele

Associated gene

Dmel\UbcE2H

Associated Insertion(s)

P{EP}UbcE2H^EP1303

Carried in Construct

Also Known As

EP(X)1303

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-, Fernandez-Funez et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}UbcE2H^EP1303

Cytology

Description

The P{EP} insertion is 1439bp upstream of the putative ATG start codon in the opposite orientation to the transcription unit.

(Fernandez-Funez et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:8,091,297..8,091,297 [-]

(Branco et al., 2008, Buff et al., 2007, Gene Disruption Project members, 2001-, Fernandez-Funez et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^82Q.UAS

(Fernandez-Funez et al., 2000)

modeled by Hsap\ATXN1^30Q.UAS

(Fernandez-Funez et al., 2000)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Ubc-E2H^EP1303 under the control of Scer\GAL4^GMR.PF does not result in a rough eye phenotype.

(Shulman and Feany, 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

UbcE2H^EP1303, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

UbcE2H^EP1303, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

NOT Suppressor of

Statement

Reference

UbcE2H^EP1303, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

UbcE2H^EP1303, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

UbcE2H^EP1303, Scer\GAL4^GMR.PF is an enhancer of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

NOT Enhancer of

Statement

Reference

UbcE2H^EP1303, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

UbcE2H^EP1303, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

NOT Suppressor of

Statement

Reference

UbcE2H^EP1303, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is not modified if the flies are also carrying Ubc-E2H^EP1303.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

17216

w¹¹¹⁸ P{EP}UbcE2H^EP1303

Notes on Origin

Discoverer

Selected as: an insertion line that modifies the eye phenotype caused by expression of Ppt1^Scer\UAS.cKa under the control of Scer\GAL4^GMR.PF when co-expressed using Scer\GAL4^GMR.PF.

(Buff et al., 2007)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

EP(X)1303

(Shulman and Feany, 2003)

Ubc-E2H^EP1303

UbcE2H^EP1303

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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