FB2026_02 , released June 18, 2026
Allele: Dmel\sydZ
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General Information
Symbol
Dmel\sydZ
Species
D. melanogaster
Name
FlyBase ID
FBal0120322
Feature type
allele
Associated gene
Dmel\syd
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Bowman et al., 2000)
Progenitor genotype
Cytology
Description

G to A point mutation at the conserved 3' splice acceptor site of the same intron/exon boundary affected in sydD1. As a result, intron splicing fails, causing a premature stop codon to be encoded after amino acid 514 (just N terminal to the predicted transmembrane region). The premature stop codon truncates the protein by 58% of its length.

(Bowman et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:7,930,086..7,930,086 [-]
Nucleotide change:

G7930086A

Reported nucleotide change:

G?A

Comment:

The G to A point mutation lies at the conserved 3' splice acceptor site of the same intron/exon boundary affected in sydD1. As a result, intron splicing fails, causing a premature stop codon to be encoded after amino acid 514.

(Bowman et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Shows strong "tail flipping" phenotype and mild distal larval sluggishness. Shows no defects, such as rough eyes or reduced imaginal tissue, associated with mitosis. Axonal membrane bound cargoes and motors accumulate within the segmental nerves.

      (Bowman et al., 2000)
      External Data
      Interactions
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      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sydZ
      Name Synonyms
      Secondary FlyBase IDs
        References (1)