FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mus101lcd
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General Information
Symbol
Dmel\mus101lcd
Species
D. melanogaster
Name
lethal compact disc
FlyBase ID
FBal0120441
Feature type
allele
Associated gene
Dmel\mus101
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
transposable element activity
(Yamamoto et al., 2000)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants die as late third instar larvae or shortly after pupariation and have very small imaginal discs. Neuroblasts of hemizygous mus101lcd/Y third instar larvae have numerous chromosomes with striking undercondensation of pericentric heterochromatic regions. Most of the mitoses in larval brains show more extreme defects, characteristically grossly undercondensed chromatin or chromosome breakage. These defects are also seen in neuroblasts of mus101lcd/Df(1)HA92 female hemizygotes.

      (Yamamoto et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      mus101SM

      (Yamamoto et al., 2000)

      mus101D1

      (Yamamoto et al., 2000)
      Rescued by

      mus101lcd is rescued by mus101+t9

      (Yamamoto et al., 2000)
      Comments

      mus101SM fails to complement the larval lethality of mus101lcd. mus101lcd fails to complement the mutagen sensitivity of mus101D1.

      (Yamamoto et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mus101lcd
      Name Synonyms
      lethal compact disc
      (Yamamoto et al., 2000)
      Secondary FlyBase IDs
        References (1)