FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\PtenMGH1
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General Information
Symbol
Dmel\PtenMGH1
Species
D. melanogaster
Name
FlyBase ID
FBal0120657
Feature type
allele
Associated gene
Dmel\Pten
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Neufeld, 2001.1.11)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones show overgrowth of ddaC dendrites.

      The dendrites of ddaC neurons of mutant larvae show enhanced regeneration (after dendrite severing at 48 hours after egg laying) compared to wild-type controls. No substantial dendrite regeneration is seen after dendrite severing at 72 hours after egg laying.

      (Song et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      PtenMGH1 is a non-enhancer of visible phenotype of upd1GMR.PB

      (Bach et al., 2003)
      NOT Suppressor of
      Statement
      Reference

      PtenMGH1 is a non-suppressor of visible phenotype of upd1GMR.PB

      (Bach et al., 2003)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      PtenMGH1 is a non-enhancer of eye phenotype of upd1GMR.PB

      (Bach et al., 2003)
      NOT Suppressor of
      Statement
      Reference

      PtenMGH1 is a non-suppressor of eye phenotype of upd1GMR.PB

      (Bach et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      PtenMGH1/TorEP2353 somatic clones show a slight decrease in size compared to wild-type.

      (Zhang et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Ptendj189

      (Neufeld, 2001.1.11)
      Rescued by

      PtenMGH1 is rescued by PtenUAS.cHa/Scer\GAL4ppk.PG

      (Song et al., 2012)
      Comments

      Expression of PtenScer\UAS.cHa under the control of Scer\GAL4ppk.PG reduces the enhanced dendrite regeneration which is seen after severing of ddaC dendrites in PtenMGH1 mutant larvae.

      (Song et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Iswar Hariharan

      (Neufeld, 2001.1.11)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      PTEN-MGH1
      (Neufeld, 2001.1.11)
      PtenMGH1
      (Wang and Baker, 2015, Song et al., 2012)
      Ptenmgh1
      (Bach et al., 2003)
      ptenMGH1
      (Hafezi et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)