FlyBase Allele Report: Dmel\Lim1[R12.4]

General Information

Symbol

Dmel\Lim1^R12.4

Species

D. melanogaster

Name

FlyBase ID

FBal0120786

Feature type

allele

Associated gene

Dmel\Lim1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Pueyo et al., 2000)

Progenitor genotype

Lim1^P0092

(Pueyo et al., 2000)

Cytology

Description

8kb deletion from nucleotide -2979 (0 being the start of cDNA GH04929) to +5042.

(Pueyo et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of P-stage | recessive

(Pueyo et al., 2000)

some die during pharate adult stage | recessive

(Pueyo et al., 2000)

Phenotype Manifest In

antenna

(Pueyo et al., 2000)

femur

(Pueyo et al., 2000)

mouthpart

(Pueyo et al., 2000)

sternopleural bristle

(Pueyo et al., 2000)

tibia

(Pueyo et al., 2000)

unguis

(Pueyo et al., 2000)

vibrissal bristle

(Pueyo et al., 2000)

Detailed Description

Statement

Reference

75% of legs lack a claw, the rest show a reduced claw. Femur and tibia are abnormal and balloon-shaped. More than 50% of antennae are absent, the rest being deformed. Sternopleural bristles are reduced in number or absent. Vibrissae bristles are reduced and the mouthparts slightly affected.

(Pueyo et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Lim1^R12.4 has lethal | pharate adult stage | recessive phenotype, enhanceable by al^ice

(Pueyo et al., 2000)

Enhancer of

Statement

Reference

Lim1^R12.4 is an enhancer of lethal | pharate adult stage | recessive phenotype of al^ice

(Pueyo et al., 2000)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The lethality of al^ice, Lim1^R12.4 double mutants acts during the embryonic stages, whereas lethality of either allele alone acts at the pharate adult stage.

(Pueyo et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Strong mutant.

(Pueyo et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Lim1^R12.4

dlim1^R12.4

(Pueyo et al., 2000)

lim1^R12.4

(Campbell, 2005)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close