FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\RPS6KB1D4.UAS
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General Information
Symbol
Hsap\RPS6KB1D4.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0120808
Feature type
allele
Associated gene
Hsap\RPS6KB1
Associated Insertion(s)
Carried in Construct
P{UAS-p70S6K1.D4}
Also Known As
UAS-p70S6K1-D4
Key Links
Transgenic product class
gain_of_function_variant
(Zhang et al., 2000)
missense_variant
(Zhang et al., 2000)
polypeptide_post_translational_processing_variant
(Zhang et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
gain_of_function_variant
(Zhang et al., 2000)
missense_variant
(Zhang et al., 2000)
polypeptide_post_translational_processing_variant
(Zhang et al., 2000)
Mutagen
in vitro construct
(Zhang et al., 2000)
Progenitor genotype
Carried in construct
P{UAS-p70S6K1.D4}
Cytology
Description

UAS sequences drive expression of activated Hsap\RPS6KB1. Four mitogen-induced phosphorylation sites are mutated to aspartate and glutamate residues.

(Zhang et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\RPS6KB1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When Hsap\RPS6KB1D4.Scer\UAS is driven by Scer\GAL4Act5C.PP in wild-type flies a strong resistance to rapamycin is conferred.

      (Zhang et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Hsap\RPS6KB1D4.Scer\UAS markedly suppresses the reduction in ommatidial size seen in Tsc1Scer\UAS.T:Hsap\MYC; gigΔAkt-P.Scer\UAS.T:Zzzz\FLAG; Scer\GAL4GMR.PF flies.

      (Potter et al., 2002)

      The addition of Hsap\RPS6KB1D4.Scer\UAS (driven by Scer\GAL4Act5C.PP) to TorEP2353/TorEP2353 or TorEP2353/Tork17004 animals, rescues the Tor phenotype to viability. 74% of TorEP2353/Tork17004, Hsap\RPS6KB1D4.Scer\UAS animals survive to adulthood compared to 0% without Hsap\RPS6KB1D4.Scer\UAS.

      (Zhang et al., 2000)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\RPS6KB1D4.Scer\UAS
      Hsap\RPS6KB1D4.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)