FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\msnP656A,P659A.UAS
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General Information
Symbol
Dmel\msnP656A,P659A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0121681
Feature type
allele
Associated gene
Dmel\msn
Associated Insertion(s)
Carried in Construct
P{UAS-msn.P656A,P659A}
Key Links
Transgenic product class
missense_variant
(Su et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Su et al., 2000)
Mutagen
in vitro construct
(Su et al., 2000)
Progenitor genotype
msnUAS.cSa
(Su et al., 2000)
Carried in construct
P{UAS-msn.P656A,P659A}
Cytology
Description

Construct: Amino acid replacement: P656A. Amino acid replacement: P659A.

(Su et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
msn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      msnP656A,P659A.Scer\UAS when driven by Scer\GAL469B in a msn102 background produces third instar larvae with severe defects in axonal targeting. On leaving the optic stalk axons from photoreceptors form very large axonal bundles and fail to defasciculate in the region of either the lamina or the medulla.

      (Su et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      msnP656A,P659A.UAS/Scer\GAL469B partially rescues msn102

      (Su et al., 2000)
      Comments

      When msnP656A,P659A.Scer\UAS is driven by Scer\GAL469B in msn102 embryos, a full rescue of the dorsal closure phenotype is seen, though only about 37% of embryos survive to pupal stages.

      (Su et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      msnP656A,P659A.Scer\UAS
      msnP656A,P659A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)