FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\IKKβ2
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General Information
Symbol
Dmel\IKKβ2
Species
D. melanogaster
Name
FlyBase ID
FBal0121715
Feature type
allele
Associated gene
Dmel\IKKβ
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Lu et al., 2001)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    No sequence changes detected in open reading frame; no transcript detectable from homozygotes.

    (Lu et al., 2001)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutants show no detectable induction of Dpt, CecA1 and CecA2. Attacin levels are reduced compared to wild type and Drs induction is normal. Bacteria injected into mutant larvae show increased survival compared to those injected into wild type: 6hr after infection 4-15 times as many bacteria survive in mutants than in wild type. In adults, 24hr after infection 20-350 times as many bacteria survive in mutants than in wild type. Phenotype is similar to that shown by Rel mutants and stronger than that shown by imd mutants. A small fraction (0.5%) of embryos produced by ird51/ird52 transheterozygote mothers show weakly dorsalized phenotypes.

        (Lu et al., 2001)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        IKKβ2
        ird52
        Name Synonyms
        Secondary FlyBase IDs
          References (3)