FlyBase Allele Report: Dmel\glu[88-82]

General Information

Symbol

Dmel\glu^88-82

Species

D. melanogaster

Name

FlyBase ID

FBal0121754

Feature type

allele

Associated gene

Dmel\glu

Associated Insertion(s)

P{?lacW}glu^88-82

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Steffensen et al., 2001)

Progenitor genotype

glu^k08819

(Cobbe et al., 2006, Steffensen et al., 2001)

Associated Insertion(s)

P{?lacW}glu^88-82

Cytology

Description

Internal deletion of the P{lacW} element, with the heat shock promoter, part of the Ecol\lacZ reporter gene remaining and the P element terminal repeats remaining.

(Cobbe et al., 2006)

A large internal region of the P{lacW} element is deleted.

(Steffensen et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

AJ543653

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

glu^88-82 mutant embryos have a lower ratio of mitosis to apoptosis compared to wild-type embryos. This ratio decreases further with age. glu^88-82 both enhances and suppresses PEV of eye colour in In(1)w^m4h flies, but the suppressor behaviour occurs at a far higher frequency. The enhancement of PEV by glu^88-82 in flies carrying the P{hsp26-pt-T}118E-10 insertion is more apparent in female progeny. The same is true for the P{hsp26-pt-T}39C-72 insertion.

(Cobbe et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

In(1)w^m4, glu^88-82 has suppressor of variegation phenotype, non-suppressible by Cap-G⁶⁴

(Cobbe et al., 2006)

In(1)w^m4, glu^88-82 has suppressor of variegation phenotype, non-suppressible by barr^L305

(Cobbe et al., 2006)

NOT Suppressor of

Statement

Reference

glu^88-82 is a non-suppressor of enhancer of variegation phenotype of Cap-G⁶⁴

(Cobbe et al., 2006)

glu^88-82 is a non-suppressor of enhancer of variegation phenotype of barr^L305

(Cobbe et al., 2006)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Intermediate eye pigment levels are observed in glu^88-82, Cap-G⁶⁴ and glu^88-82, barr^L305 double mutants with a In(1)w^m4h background, showing that glu^88-82 suppressor effects of PEV are not dominant over the enhancer activities of Cap-G⁶⁴ and barr^L305.

(Cobbe et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9425

w^*; glu^88-82/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ543653

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

glu^88-82

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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