FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\drm6
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General Information
Symbol
Dmel\drm6
Species
D. melanogaster
Name
FlyBase ID
FBal0121793
Feature type
allele
Associated gene
Dmel\drm
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Green et al., 2002)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T. Amino acid replacement: R46C.

(Green et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:3,545,722..3,545,722 [+]
Nucleotide change:

C3545722T

Amino acid change:

R46C | drm-PA; R46C | drm-PB; R46C | drm-PC

Reported amino acid change:

R46C

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Green et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones in the eye do not result in retinal defects.

      (Bras-Pereira et al., 2006)

      drm3/drm6 embryos have short and wide hindguts with an excessive number of cells in their circumference.

      (Johansen et al., 2003)

      Mutant embryos have hindgut defects. The proventriculus is both morphologically and functionally defective.

      (Green et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      drm6/drm3 has embryonic hindgut phenotype, suppressible by Scer\GAL4drm.7.1/upd1UAS.cZa

      (Johansen et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of upd1Scer\UAS.cZa under the control of Scer\GAL4drm.7.1 significantly rescues the drm3/drm6 mutant hindgut phenotype; the hindgut is more elongated and has fewer cells in its circumference than in drm3/drm6 embryos.

      (Johansen et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      drm alleles form an allelic series: drm5 < drm2 < drm4 < drm1 < drm6 = drm3 < Df(2L)drm-P1 = Df(2L)drm-P2.

      (Green et al., 2001)

      drm alleles form an allelic series: drm5 < drm2 < drm4 < drm1 < drm3 = drm6 < Df(2L)drm-P1 = Df(2L)drm-P2.

      (Green et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      drm6
      (Tena et al., 2007, Bras-Pereira et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)