FlyBase Allele Report: Dmel\TfAP-2[3]

General Information

Symbol

Dmel\TfAP-2³

Species

D. melanogaster

Name

FlyBase ID

FBal0123331

Feature type

allele

Associated gene

Dmel\TfAP-2

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Monge et al., 2001)

Mutagen

ethyl methanesulfonate

(Monge et al., 2001)

Progenitor genotype

Cytology

Description

Nucleotide substitution: TG is mutated to AG in intron 1, creating a new splice acceptor.

(Monge et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:21,609,407..21,609,407 [+]

Nucleotide change:

T21609407A

Reported nucleotide change:

T?A

Comment:

Nucleotide substitution: TG to AG, creating a new splice acceptor.

(Mitchell, 2004.1.20, Monge et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Monge et al., 2001)

some die during immature adult stage | recessive

(Monge et al., 2001)

Phenotype Manifest In

adult head

(Monge et al., 2001)

labellum

(Monge et al., 2001)

leg

(Monge et al., 2001)

leg joint

(Monge et al., 2001)

proboscis

(Monge et al., 2001)

pseudotrachea

(Monge et al., 2001)

Detailed Description

Statement

Reference

Pharate pupae and the few eclosing adults show a short leg phenotype. Leg length = 30% wild type. Tarsal joints are lacking. Legs are non-functional. The proximodistal order of segments is not grossly affected as landmarks for the coxa, femur, tibia, and first and last (5th) tarsal segments (sex comb and claws, respectively) are present in the correct order. Rows of misoriented sensory bristles indicate that proximodistal polarity is locally perturbed. The stunted legs show no nervous activity except for a faint twitching of the claws and of cuticle over the femur-tibia junction. The proboscis is reduced in length and width. Null mutants show a substantial reduction in length and width of the labellum and number of pseudo tracheal rows. The prestomal cavity is present and newly eclosed adults can drink. Clypeus, maxillary palps and antennae are apparently normal but there is increased spacing between antennae.

(Monge et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Alleles fall into an allelic series based on leg length defect. In order of decreasing severity of phenotype: AP-2² = AP-2³ = AP-2⁴ = AP-2⁵ = AP-2¹³ = AP-2¹⁴ = AP-2¹⁵ = AP-2¹⁶ = AP-2¹⁹ > AP-2⁸ = AP-2¹² > AP-2¹¹ > AP-2¹⁷ > AP-2¹⁸ > AP-2¹⁰ = AP-2⁹.

(Monge et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

AP-2³

TfAP-2³

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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