FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\TfAP-218
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General Information
Symbol
Dmel\TfAP-218
Species
D. melanogaster
Name
FlyBase ID
FBal0123334
Feature type
allele
Associated gene
Dmel\TfAP-2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Monge et al., 2001)
Mutagen
ethyl methanesulfonate
(Monge et al., 2001)
Progenitor genotype
Cytology
Description

Amino acid replacement: R306I. Nucleotide substitution: G?T.

(Monge et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:21,612,319..21,612,319 [+]
Nucleotide change:

G21612319T

Reported nucleotide change:

G?T

Amino acid change:

R306I | TfAP-2-PA; R310I | TfAP-2-PB; R304I | TfAP-2-PC; R316I | TfAP-2-PD; R312I | TfAP-2-PE; R310I | TfAP-2-PF

Reported amino acid change:

R306I

(Monge et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pharate pupae and the few eclosing adults show a short leg phenotype. Leg length = 85-90% wild type. All joints are present, but frequently necrotic. Mutants have severely ataxic legs and are generally unable to stand, though newly eclosed adults can thrash their legs vigorously when supine.

      (Monge et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Alleles fall into an allelic series based on leg length defect. In order of decreasing severity of phenotype: AP-22 = AP-23 = AP-24 = AP-25 = AP-213 = AP-214 = AP-215 = AP-216 = AP-219 > AP-28 = AP-212 > AP-211 > AP-217 > AP-218 > AP-210 = AP-29.

      (Monge et al., 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AP-218
      TfAP-218
      Name Synonyms
      Secondary FlyBase IDs
        References (1)