FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sli1912
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General Information
Symbol
Dmel\sli1912
Species
D. melanogaster
Name
FlyBase ID
FBal0123702
Feature type
allele
Associated gene
Dmel\sli
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Battye et al., 2001)
Mutagen
ethyl methanesulfonate
(Battye et al., 2001)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C3117T.

(Battye et al., 2001)

Amino acid replacement: Q?term.

(Battye et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:15,875,528..15,875,528 [-]
Nucleotide change:

C15875528T

Reported nucleotide change:

C3117T

Amino acid change:

Q1013term | sli-PA; Q1013term | sli-PB; Q1037term | sli-PC; Q1013term | sli-PD; Q1037term | sli-PE; Q1037term | sli-PF

Reported amino acid change:

Q?term

(Battye et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      7.4% of expected mutant embryos hatch as first instar larvae. The latest observed stage of mutants is pupa. Nerve cord length is 92% of embryo length. Midline guidance failure of repellence phenotype, evidenced by midline crossing, is moderate. Longitudinal connectives wander close to the midline. 2.9 ventral oblique muscles per segment cross the midline on the dorsal surface of the ventral nerve cord, instead of having migrated to the edges and inserted into the ectoderm.

      (Battye et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      sli1912 has larval ventral nerve cord phenotype, enhanceable by robo[+]/robo11

      (Battye et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Percentage of segments with midline crossovers in robo1/sli1912 transheterozygotes is 60%.

      (Battye et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Protein null.

      (Battye et al., 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sli1912
      slit1912
      (Battye et al., 2001)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)