FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\key4
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General Information
Symbol
Dmel\key4
Species
D. melanogaster
Name
FlyBase ID
FBal0123804
Feature type
allele
Associated gene
Dmel\key
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Rutschmann et al., 2000)
Mutagen
ethyl methanesulfonate
(Rutschmann et al., 2000)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q310term.

(Rutschmann et al., 2000)

Nucleotide substitution: C1192T.

(Rutschmann et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:24,785,849..24,785,849 [-]
Nucleotide change:

C24785849T

Reported nucleotide change:

C1192T

Amino acid change:

Q310term | key-PA; Q310term | key-PB

Reported amino acid change:

Q310term

(Rutschmann et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous flies show a reduced resistance to infection by the E. coli compared to controls.

      (Tauszig-Delamasure et al., 2002)

      Mutant flies show significantly lower resistance to E.coli infections than wild-type flies. Mutant flies show the same level of resistance to B.bassiana (when their cuticles are coated with spores) as wild-type flies.

      (Rutschmann et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      key4/key1 is a suppressor of abnormal neuroanatomy | adult stage | progressive | conditional phenotype of norpAEE5

      (Chinchore et al., 2012)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      key4
      (Chinchore et al., 2012, Tauszig-Delamasure et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)