FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\BgbD
Open Close
General Information
Symbol
Dmel\BgbD
Species
D. melanogaster
Name
FlyBase ID
FBal0126654
Feature type
allele
Associated gene
Dmel\Bgb
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kaminker et al., 2001)
Progenitor genotype
Cytology
Description

Amino acid replacement: G116R.

(Kaminker, 2005.6.7)

Nucleotide substitution: G808A. Amino acid replacement: G?R.

(Kaminker et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:1,640,427..1,640,427 [+]
Nucleotide change:

G1640427A

Reported nucleotide change:

G808A

Amino acid change:

G145R | Bgb-PA; G145R | Bgb-PB

Reported amino acid change:

G116R

(Kaminker, 2005.6.7, Kaminker et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  acute myeloid leukemia
      modeled by Hsap\RUNX1::Hsap\RUNX1T1UAS.cSa
      (Sinenko et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      One copy of BgbD has no effect on hemocyte proliferation in third instar larvae.

      (Sinenko et al., 2010)

      The axons of the lch1 neurons do not follow the segmental nerve but incorrectly project towards the lch5 and follow the intersegmental nerve to the midline in homozygous embryos. This phenotype shows incomplete expressivity. A similar phenotype, with higher expressivity, is seen in BgbD/Df(3L)Bgb-K4 embryos. Homozygous embryos do not have segmentation defects. Homozygous clones in the eye have no defects in the external morphology of the facets. The morphology of all retinal cells is normal.

      (Kaminker et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      BgbD/Bgb[+] is an enhancer of increased cell number | third instar larval stage phenotype of Hsap\RUNX1::Hsap\RUNX1T1UAS.cSa, Scer\GAL4Hml.Δ

      (Sinenko et al., 2010)

      BgbD/Bgb[+] is an enhancer of visible | heat sensitive phenotype of lzts1

      (Kaminker et al., 2001)

      BgbD/Df(3L)Bgb-K4 is an enhancer of visible | heat sensitive phenotype of lzts1

      (Kaminker et al., 2001)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      BgbD/Bgb[+] is an enhancer of embryonic/larval hemocyte | third instar larval stage phenotype of Hsap\RUNX1::Hsap\RUNX1T1UAS.cSa, Scer\GAL4Hml.Δ

      (Sinenko et al., 2010)

      BgbD/Bgb[+] is an enhancer of eye phenotype of lzts1

      (Kaminker et al., 2001)

      BgbD/Df(3L)Bgb-K4 is an enhancer of eye phenotype of lzts1

      (Kaminker et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Rare lzts1 ; BgbD/Df(3L)Bgb-K4 escapers are seen. These flies are extremely weak and can only be rescued if they are dissected from the pupal case. They have a strong adult eye phenotype that is identical to that of a null lz mutant.

      (Kaminker et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference

      One copy of BgbD moderately enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1Scer\UAS.cSa is expressed under the control of Scer\GAL4Hml.Δ.

      (Sinenko et al., 2010)
      Complementation and Rescue Data
      Rescued by

      BgbD is rescued by Bgbhs.PK

      (Kaminker et al., 2001)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: an enhancer of the lzts1 eye phenotype.

      (Kaminker et al., 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      BgbD
      (Sinenko et al., 2010)
      en(lz)D
      (Kaminker et al., 2001)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)