FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SseC497S.UAS.Tag:HA
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General Information
Symbol
Dmel\SseC497S.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0127268
Feature type
allele
Associated gene
Dmel\Sse
Associated Insertion(s)
Carried in Construct
P{UAS-Sse.C497S.T:Ivir\HA1}
Also Known As
UAS-HA-SseC497S, UAS-6HA-Sse C497S
Key Links
Transgenic product class
missense_variant
(Jager et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Jager et al., 2001)
Mutagen
in vitro construct
(Jager et al., 2001)
Progenitor genotype
SseUAS.Tag:HA
(Jager et al., 2001)
Carried in construct
P{UAS-Sse.C497S.T:Ivir\HA1}
Cytology
Description

Construct: Amino acid replacement: C497S.

(Jager et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sse
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The maternal effect lethality and cellularisation defects of embryos derived from females carrying two copies of thrΔVQ.T:Hsap\MYC and raised at 18oC are suppressed by one copy of Sse13m; only 7% of these embryos have cellularisation defects. If SseC497S.Scer\UAS.T:Ivir\HA1 is expressed in this background under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 the frequency and severity of cellularisation defects is unaffected.

      (Herzig et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      SseC497S.UAS.Tag:HA/Scer\GAL469B fails to rescue Ssedft

      (Cipressa et al., 2016)

      SseC497S.UAS.Tag:HA/Scer\GAL4da.G32 fails to rescue Sse13m

      (Jager et al., 2001)
      Comments

      Expression of SseC497S.Scer\UAS.T:Ivir\HA1 driven by Scer\GAL469B fails to rescue telomeric fusions and endoreduplication phenotypes in Ssedft/Ssedft larval brain neuroblasts.

      (Cipressa et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SseC497S.Scer\UAS.T:Ivir\HA1
      SseC497S.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (4)