FlyBase Gene Report: Dmel\Sse

General Information

Symbol

Dmel\Sse

Species

D. melanogaster

Name

Separase

Annotation Symbol

CG10583

Feature Type

protein_coding_gene

FlyBase ID

FBgn0035627

Gene Model Status

Current

Stock Availability

9 publicly available

Enzyme Name (EC)

Gene Summary

Separase (Sse) encodes an endoprotease. Together with the product of thr, it forms a complex which cleaves a subunit of the cohesin complex during meiosis, thereby allowing separation of the sister chromatids. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(3)SG14

Key Links

Genomic Location

Cytogenetic map

64E1-64E1

Sequence location

3L:5,659,700..5,662,247 [-]

Recombination map

3-15

RefSeq locus

NT_037436 REGION:5659700..5662247

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables cysteine-type endopeptidase activity

inferred from genetic interaction with FLYBASE:uno; FB:FBgn0033258

(Weber et al., 2020)

enables protein binding

inferred from physical interaction with UniProtKB:P42286

(Jager et al., 2001)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables cysteine-type endopeptidase activity

inferred from electronic annotation with InterPro:IPR005314, InterPro:IPR030397

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with UniProtKB:Q03018

(Gene Ontology Curators, 2002-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in meiotic chromosome separation

inferred from genetic interaction with FLYBASE:uno; FB:FBgn0033258

(Weber et al., 2020)

involved_in mitotic sister chromatid segregation

inferred from mutant phenotype

(Jager et al., 2001)

involved_in telomere capping

inferred from mutant phenotype

(Cipressa et al., 2016)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in mitotic sister chromatid segregation

traceable author statement

(Lee and Orr-Weaver, 2003)

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR005314, InterPro:IPR030397

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in chromosome, telomeric repeat region

inferred from direct assay

(Cipressa et al., 2016)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from electronic annotation with InterPro:IPR005314

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

SEPARASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

cysteine-type endopeptidase activity

Summaries

Gene Snapshot

Gene Group (FlyBase)

SEPARASES -: Separases are cysteine-type endopeptidases that belong to MEROPS family C50. They degrade a conserved cohesin subunit during mitosis, thereby allowing sister chromatid separation. (Adapted from FBrf0139669.)

Summary (Interactive Fly)

endopeptidase required for sister chromatid separation during mitosis - required for homolog and sister disjunction during male meiosis - together with Three rows it forms a complex which cleaves a subunit of the cohesin complex during meiosis

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Sse for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VRN6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Sse-RA

FBtr0077125

NM_079211

2177

634

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Sse-PA

FBpp0076831

72.9

634

6.56

Q9VRN6

NP_523935

AAF50757

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VRN6

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sse using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sse_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.33

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in chromosome, telomeric repeat region

inferred from direct assay

(Cipressa et al., 2016)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sse in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Sse

View exonic expression by tissue for Dmel\Sse

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0035627

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38640/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035627

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035627

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035627

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10583

Flygut - An atlas of the Drosophila adult midgut

FBgn0035627

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Sse

Transgenic constructs containing regulatory region of Sse

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(3L)Exel6106

(Ryder, 2004.4.26)

Df(3L)SseA

(Jager et al., 2001)

Df(3L)ZN47

(Cipressa et al., 2016, Jager et al., 2001)

Gene not disrupted in

Df(3L)hry-i22

(Jager et al., 2001)

Df(3L)Scf-R6

(Jager et al., 2001)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^insc-Mz1407

Sse^GD6697

lethal | recessive

Sse^C93

lethal - all die before end of larval stage | recessive

Sse^13m

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Sse^GD6697

viable

Sse^f03027

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Sse^GD6697

viable, with Scer\GAL4^tin.CΔ4

Sse^GD6697

Sterility

Allele

female sterile, with Scer\GAL4^{VP16.mat.αTub67C}

fertile

Sse^f03027

Other Phenotypes

Allele

abnormal cell cycle | embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

Sse^{RNAi.147.UASp}

abnormal endomitotic cell cycle | larval stage

Sse^dft

abnormal endomitotic cell cycle | larval stage, with Scer\GAL4^69B

Sse^GD6697

abnormal endomitotic cell cycle | larval stage (with Df(3L)ZN47)

Sse^dft

abnormal endomitotic cell cycle | larval stage (with Sse^13m)

Sse^dft

abnormal endomitotic cell cycle | larval stage (with Sse^dft)

Sse^13m

abnormal meiotic cell cycle | embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

Sse^{RNAi.213.UASp}

abnormal mitotic cell cycle

abnormal mitotic cell cycle (with Df(3L)SseA)

Sse^13m

abnormal mitotic cell cycle | somatic clone | third instar larval stage

Sse^C93

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

Sse^GD6697

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Sse^GD6697

abnormal size

Sse^13m

abnormal size | larval stage

Sse^13m

decreased occurrence of cell division

Sse^13m

decreased occurrence of cell division | larval stage

Sse^13m

increased cell size | third instar larval stage

Sse^13m

some die during larval stage | recessive

Sse^13m

some die during pupal stage, with Scer\GAL4^pnr-MD237

Sse^GD6697

visible, with Scer\GAL4^pnr-MD237

Sse^GD6697

wild-type

Sse^+t10

Phenotype manifest in

Allele

cell cycle

Sse^13m

chromosome | larval stage

Sse^dft

chromosome | larval stage, with Scer\GAL4^69B

Sse^GD6697

chromosome | larval stage (with Df(3L)ZN47)

Sse^dft

chromosome | larval stage (with Sse^13m)

Sse^dft

chromosome | larval stage (with Sse^dft)

Sse^13m

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

Sse^GD6697

imaginal disc

Sse^13m

imaginal disc | larval stage

Sse^13m

larval brain | somatic clone | third instar larval stage

Sse^C93

larval neuroblast | larval stage

Sse^dft

larval neuroblast | larval stage, with Scer\GAL4^69B

Sse^GD6697

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

Sse^GD6697

larval neuroblast | larval stage (with Df(3L)ZN47)

Sse^dft

larval neuroblast | larval stage (with Sse^13m)

Sse^dft

larval neuroblast | larval stage (with Sse^dft)

Sse^13m

larval neuroblast | somatic clone | third instar larval stage

Sse^C93

larval neuroblast | third instar larval stage (with Df(3L)Exel6106)

Sse^C93

larval neuroblast | third instar larval stage (with Sse^C93)

Sse^M13

larval neuroblast | third instar larval stage (with Sse^M13)

Sse^C93

mesonotum, with Scer\GAL4^pnr-MD237

Sse^GD6697

mitotic cell cycle

Sse^unspecified

mitotic cell cycle (with Df(3L)SseA)

Sse^13m

polar body nucleus, with Scer\GAL4^{VP16.mat.αTub67C}

trichogen cell, with Scer\GAL4^pnr-MD237

Sse^GD6697

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\ESPL1

7 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Espl1

5 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Espl1

6 of 14

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\espl1

2 of 13

Yes

Danio rerio (Zebrafish) (1)

Drer\espl1

7 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\sep-1

5 of 14

Yes

Cele\ZK430.5

5 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP001503

11 of 12

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\ESP

6 of 13

Yes

Atha\AT4G24300

2 of 13

Yes

Atha\AT5G28550

2 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\ESP1

5 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cut1

4 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Sse. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ESPL1; extra spindle pole bodies like 1, separase

7 of 14

604143

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Sse - HipHop

anti tag coimmunoprecipitation, anti tag western blot

(Cipressa et al., 2016)

Sse - Su(var)205

anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot

(Cipressa et al., 2016)

Sse - cav

pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot

(Cipressa et al., 2016)

Sse - moi

anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot

(Cipressa et al., 2016)

Sse - pim

anti tag coimmunoprecipitation, western blot, two hybrid, anti bait coimmunoprecipitation, anti tag western blot, pull down

(Cipressa et al., 2016, Jager et al., 2004, Leismann and Lehner, 2003, Jager et al., 2001)

Sse - thr

two hybrid, anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot

(Jager et al., 2001)

Sse - ver

pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot

(Cipressa et al., 2016)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Sse

suppressible

Su(var)205

(Cipressa et al., 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Ji et al., 2005)

enhanceable

(Ji et al., 2005)

suppressible

(Herzig et al., 2002)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64103

DroID - A comprehensive database of gene and protein interactions.

FBgn0035627

MIST (genetic) - An integrated Molecular Interaction Database

38640

MIST (protein-protein) - An integrated Molecular Interaction Database

38640

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-15

Cytogenetic map

64E1-64E1

Sequence location

3L:5,659,700..5,662,247 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

64E1-64E1

Limits computationally determined from genome sequence between P{PZ}sinu⁰⁶⁵²⁴ and P{PZ}Bre1⁰¹⁶⁴⁰

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-15

(FlyBase, 2016)

3-13.5

(Comeron et al., 2012)

3-26.6

(Gatti and Baker, 1989)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

91762

P{UAS-Sse.T:Ivir\HA1}I.1, w^*

18610

w¹¹¹⁸; PBac{WH}Sse^f03027

91763

w^*; P{UAS-Sse.C497S.T:Ivir\HA1}II.1

58584

y¹ w^*; Mi{MIC}Sse^MI13100 sif^MI13100

8988

mwh¹ Sse^13m red¹ e¹/TM6B, Tb⁺

FlyORF

F001501

M{UAS-Sse.ORF}ZH-86Fb

10583R-1

v106237

v45091

w¹¹¹⁸; P{GD6697}v45091

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (24)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD08709

Other clones

DPiM_LD08709

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0035627

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0035627

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Cipressa et al., 2016)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion.

(Bard et al., 2006)

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

Sse is required for sister chromatid separation.

(Jager et al., 2001)

Candidate gene for tibia length quantitative trait locus.

(Macdonald and Goldstein, 1999)

Relationship to Other Genes

Source for database merge of

Source for merge of: Sse l(3)SG14

(Jager et al., 2001)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Sse CG10583

(Lehner, 2001.3.6)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG10583

(Hosono et al., 2015, Lin et al., 2015, Cui et al., 2013, Schertel et al., 2013, Chen et al., 2012, Keleman et al., 2009.8.5)

SSE

(Nagao and Yanagida, 2002, Ross and Cohen-Fix, 2002)

Sse

(Meyer-Nava et al., 2020, Solis et al., 2017, Blattner et al., 2016, Cipressa et al., 2016, Guo et al., 2016, Liang et al., 2014, Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Georlette et al., 2007, Stroschein-Stevenson et al., 2006, Dorsett et al., 2005, Jager et al., 2004)

l(3)13m-281

(Gatti and Baker, 1989)

l(3)SG14

(Macdonald and Goldstein, 1999)

sse

(Wang et al., 2019, Cui et al., 2013, Slack et al., 2006, Ji et al., 2005, Williams et al., 2003, Bernard and Allshire, 2002)

Name Synonyms

Separase

(Cipressa et al., 2016, Somma et al., 2008, Dorsett et al., 2005, Leismann and Lehner, 2003, Heidmann et al., 2001)

lethal(3)SG14

separase

(Rivera and Losada, 2006, Slack et al., 2006, Heidmann et al., 2003, Lehner, 2003)

Secondary FlyBase IDs

FBgn0002461

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 35 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38640

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VRN6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VRN6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VRN6

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0035627

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38640/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035627

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035627

FlyMine - An integrated database for Drosophila genomics

FBgn0035627

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10583

MARRVEL_MODEL - MARRVEL (model organism gene)

38640

Linkouts

BioGRID - A database of protein and genetic interactions.

64103

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0035627

DroID - A comprehensive database of gene and protein interactions.

FBgn0035627

DRSC - Results frm RNAi screens

FBgn0035627

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sse_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035627

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0035627

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10583

Flygut - An atlas of the Drosophila adult midgut

FBgn0035627

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034808

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

38640

MIST (protein-protein) - An integrated Molecular Interaction Database

38640

References (74)

The following external sites may use different assemblies or annotations than FlyBase.

-0.33

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