FB2026_02 , released June 18, 2026
Allele: Dmel\RafS743A.hs
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General Information
Symbol
Dmel\RafS743A.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0127910
Feature type
allele
Associated gene
Dmel\Raf
Associated Insertion(s)
Carried in Construct
P{hs-Raf.S743A}
Key Links
Transgenic product class
missense_variant
(Radke et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Radke et al., 2001)
Mutagen
in vitro construct
(Radke et al., 2001)
Progenitor genotype
Carried in construct
P{hs-Raf.S743A}
Cytology
Description

An Hsp70 promoter drives expression of mutant Raf (carries the amino acid replacement S743A).

(Radke et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Raf
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      RafS743A.hs partially rescues Raf11

      (Radke et al., 2001)
      Comments

      Expression of phlS743A.hs in phl11/Y embryos which lack both maternal and zygotic phl function results in an "imperfect torso phenotype" in 99% of the embryos; they have denticle belts of reduced width and are twisted, in addition to having the head and tail defects associated with the "torso" phenotype. The distance between Keilin's organs is reduced compared to wild type. The distance between the ventral black dots is reduced compared to wild type. The distance between the ventral and dorsal black dots is also decreased.

      (Radke et al., 2001)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      D-rafS743A
      (Radke et al., 2001)
      RafS743A.hs
      phlS743A.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (1)