FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NctR46
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General Information
Symbol
Dmel\NctR46
Species
D. melanogaster
Name
FlyBase ID
FBal0129200
Feature type
allele
Associated gene
Dmel\Nct
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: W625term.

    (Chung and Struhl, 2001)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:24,853,885..24,853,885 [+]
    Nucleotide change:

    G24853885A

    Amino acid change:

    W625term | nct-PA; W625term | nct-PC; W625term | nct-PD; W625term | nct-PE

    Reported amino acid change:

    W625term

    Comment:

    G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

    (Chung and Struhl, 2001)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Follicle stem cell clones homozygous for nctR46 persist in the ovariole approximately as well as control clones over a 14 day period.

        (Vied and Kalderon, 2009)

        Wing notching and wing vein thickening in somatic clones indicate a loss of N signalling. Excess neuroblast segregation in embryos derived from germ-line clones also indicates a loss of N signalling and Psn function.

        (Chung and Struhl, 2001)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        NctR46
        (Langridge and Struhl, 2017)
        nctR46
        (Yang and Deng, 2018, Jia et al., 2014, Vied and Kalderon, 2009)
        Name Synonyms
        Secondary FlyBase IDs
          References (6)