FB2026_02 , released June 18, 2026
Allele: Dmel\btl::EgfrUAS.cDa
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General Information
Symbol
Dmel\btl::EgfrUAS.cDa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Dossenbach
FlyBase ID
FBal0130481
Feature type
allele
Associated gene
btl::Egfr
Associated Insertion(s)
Carried in Construct
P{UAS-btl::Egfr.D}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Dossenbach et al., 2001)
Progenitor genotype
Carried in construct
P{UAS-btl::Egfr.D}
Cytology
Description

UAS regulatory sequences drive expression of a chimeric protein consisting of the extracellular and transmembrane domains of btl fused to the intracellular domain of Egfr.

(Dossenbach et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
btl::Egfr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of btl::EgfrScer\UAS.cDa under the control of Scer\GAL4btl.PS at both 18oC and 25oC in btlH82Δ3 embryos can rescue all primary branches of the tracheal system, although at reduced frequencies. Many embryos have dorsal and ganglionic branch defects in half or more of the segments. The lateral trunk fuses only sporadically, although the dorsal trunk shows complete fusion in most embryos. The visceral branch is misguided in some embryos. The number of terminal tracheal cells is significantly reduced compared to wild type. Expression of btl::EgfrScer\UAS.cDa under the control of Scer\GAL4btl.PS significantly rescues tracheal development in btlH82Δ3 stumps09904b double mutant embryos. The dorsal trunk is disrupted in some embryos, some dorsal branches are missing or misguided and the lateral trunk fails to fuse. Some of the ganglionic branches fail to form and do not migrate in the proper direction.

      (Dossenbach et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      btl::EgfrScer\UAS.cDa
      btl::EgfrUAS.cDa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Dossenbach
      (Dossenbach et al., 2001)
      Secondary FlyBase IDs
        References (1)