FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: P1\creEBD251.UASp
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General Information
Symbol
P1\creEBD251.UASp
Species
P. Enterobacteria phage P1
Name
FlyBase ID
FBal0130841
Feature type
allele
Associated gene
P1\cre
Associated Insertion(s)
Carried in Construct
P{UASp-cre-EBD251}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Heidmann and Lehner, 2001)
Progenitor genotype
Carried in construct
P{UASp-cre-EBD251}
Cytology
Description

UASp regulatory sequences drive expression of a ligand-inducible recombinase (P1cre::EBD) that is composed of the P1\cre recombinase coding region fused to the D linker domain and E ligand-binding domain of Hsap\ESR1.

(Heidmann and Lehner, 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
P1cre::EBD
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In the absence of estrogen, most animals carrying P1\creEBD251.Scer\UAS.P\T.T:Hsap\ESR1 expressed under the control of Scer\GAL4ey.PH have normal eye morphology. In the presence of estrogen, animals carrying P1\creEBD251.Scer\UAS.P\T.T:Hsap\ESR1 expressed under the control of Scer\GAL4ey.PH all have rough eyes. Lower concentrations of estrogen result in a reduced severity of the phenotype.

      (Heidmann and Lehner, 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The T:Hsap\ESR1 hormone binding domain tag results in the level of recombinase activity being regulated by estrogen.

      (Heidmann and Lehner, 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      P1\creEBD251.Scer\UAS.P\T.T:Hsap\ESR1
      P1\creEBD251.UASp
      Name Synonyms
      Secondary FlyBase IDs
        References (1)