FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: P1\cre
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General Information
Symbol
P1\cre
Species
P. Enterobacteria phage P1
Name
cre recombinase
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0017409
Gene Model Status
Not Applicable
Stock Availability
21 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Cre

Foreign Gene Data

Foreign sequence; species == Bacteriophage P1; gene == 'cre'; UniProt:P06956.

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 293 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of P1\cre
Transgenic constructs containing regulatory region of P1\cre
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4hs.2sev
partially lethal - majority die, with Scer\GAL4elav-C155
viable, with Scer\GAL4prd.RG1
Other Phenotypes
Allele
abnormal locomotor behavior | adult stage, with Scer\GAL4elav-C155, cazlox
abnormal size | adult stage
increased cell death, with Scer\GAL4dpp.blk1
increased cell death, with Scer\GAL4en-e16E
increased cell death | larval stage, with Scer\GAL4dpp.blk1
increased cell death | larval stage, with Scer\GAL4en-e16E
short lived, with Scer\GAL4elav-C155
short lived, with Scer\GAL4elav-C155, cazlox
some die during P-stage, with Scer\GAL4elav-C155, cazlox
uncoordinated, with Scer\GAL4elav-C155
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4elav-C155
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4GMR.PF
visible | drug conditional, with Scer\GAL4ey.PH
Phenotype manifest in
Allele
embryonic/larval hypodermal muscle cell, with Scer\GAL4Mef2.PR
eye, with Scer\GAL4elav-C155
eye, with Scer\GAL4GMR.PF
eye | drug conditional, with Scer\GAL4ey.PH
retina, with Scer\GAL4GMR.PF
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4dpp.blk1
wing blade posterior compartment, with Scer\GAL4en-e16E
wing disc, with Scer\GAL4dpp.blk1
wing disc, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (0)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    Class of Gene
    Stocks and Reagents
    Other Comments

    In the presence of a P1\cre transgene driven by a dual Hsp70-Dmau\mariner\T promoter, a w reporter gene flanked by P1\loxP sites is excised with virtually 100% efficiency both in somatic and germ cells. A strong maternal effect, resulting from P1\cre recombinase present in the oocyte, is observed as white or mosaic eye colour in F1 progeny. Excision in germ cells of the F1 yields a strong grand-maternal effect, observed as a highly skewed ratio of eye-colour phenotypes in the F2 generation. The excision reactions of P1\cre/P1\loxP and the related Scer\FLP1/Scer\FRT system are used to create lines in which transgenes are at exactly allelic sites in homologous chromosomes.

    (Siegal and Hartl, 1996)
    Relationship to Other Genes
    Source for database merge of
    Additional comments
    Nomenclature History
    Source for database identify of
    Nomenclature comments
    Etymology
    Synonyms and Secondary IDs (7)
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    Study result (0)
    Result
    Result Type
    Title
    External Crossreferences and Linkouts ( 0 )
    References (49)