FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CSN5unspecified
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General Information
Symbol
Dmel\CSN5unspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0131309
Feature type
allele
Associated gene
Dmel\CSN5
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        CSN5unspecified mutant egg chambers display a variety of phenotypes: apoptosis of germ cells; extra or fewer nurse cells (germ cell numbers per egg chamber vary from 2-32); fusion of adjacent egg chambers, sometimes resulting in multiple germline cysts in the same, aberrant egg chamber; and occasional tumorous-like ovarioles filled with large numbers of germline cysts not separated by follicle cells. In some CSN5unspecified germline clones, nurse cell nuclei are much larger than normal and sometimes the nuclei within a particular chamber differ dramatically in size.

        (Doronkin et al., 2003)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Unlike either single heterozygote, ovaries from CSN5unspecified; lin19k01207 transheterozygous females display various defects: cell death, abnormal number of nurse cells per egg chamber, and loss of stalk cells. The ovary phenotype of CSN5unspecified mutants is not suppressed by mei-W68 or mei-41.

        (Doronkin et al., 2003)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        CSN5unspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (4)