FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\twinKG00877
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General Information
Symbol
Dmel\twinKG00877
Species
D. melanogaster
Name
FlyBase ID
FBal0131568
Feature type
allele
Associated gene
Dmel\twin
Associated Insertion(s)
P{3'SUPor-P}KG00877b
P{5'SUPor-P}KG00877a
Carried in Construct
Also Known As
ccr4KG877
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Levis, 2003.3, Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{3'SUPor-P}KG00877b
P{5'SUPor-P}KG00877a
Cytology
Description

Two insertions into twin, one in the 5' UTR (P{5'SUPor-P}twinKG00877a) and one in the large fourth intron (P{3'SUPor-P}twinKG00877b). Neither P-element is complete; the insertion in the 5' UTR lacks its 3' end, while the insertion in the fourth intron lacks its 5' end.

(Temme et al., 2004)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos derived from twinKG00877/Df(3R)Exel6198 females mated to wild-type males show 31% lethality. Syncytial blastoderm nuclei of these embryos divide asynchronously, in contrast to wild type.

      twinKG00877/Df(3R)crb-F89-4 females show a number of ovarian defects; 87.7% of egg chambers are wild-type, but 0.5% have less than 15 nurse cells, 5% have more than 15 nurse cells and 7% show degeneration.

      (Zaessinger et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Separable from: cavKG00877. The "KG00877" line contains 2 separate insertions; P{3'SUPor-P}twinKG00877b (corresponding to the site of the flanking sequence BH614837) which maps within twin and P{5'SUPor-P}twinKG00877a (corresponding to the site of the flanking sequence BH614838), which maps within both twin and cav (overlapping genes on opposite strands) (see FBrf0179476).

      (FlyBase, 1996-)

      "KG00877" homozygotes die as first instar larvae, but this lethality is due to an associated mutation and is not due to lack of twin function as twinKG00877/Df(3R)crb-F89-4 flies are viable.

      (Temme et al., 2004)

      An insertion in the "KG00877" chromosome maps within a region that overlaps both the twin and cav genes. The "KG00877" chromosome complements a null allele of cav for both lethality and ovarian phenotypes, indicating that the mutant phenotype is due to an effect on twin and not cav.

      (Zaessinger et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (8)
      Reported As
      Symbol Synonym
      CCR4KG00877
      (Levis, 2003.3)
      CCR4KG00877a
      CCR4KG877
      (Kadyrova et al., 2007)
      CG17741KG00877a
      ccr4KG00877
      (Semotok et al., 2005)
      ccr4KG877
      (Pesin and Orr-Weaver, 2007, Temme et al., 2004)
      twinKG00877
      (Ribot et al., 2022, Lim et al., 2009)
      twinKG877
      (Zaessinger et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)