FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sovEP1438
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General Information
Symbol
Dmel\sovEP1438
Species
D. melanogaster
Name
FlyBase ID
FBal0131611
Feature type
allele
Associated gene
Dmel\sov
Associated Insertion(s)
P{EP}sovEP1438
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EP}sovEP1438
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Huntington's disease
      modeled by Hsap\HTT128Q.1-336.UAS
      (Branco et al., 2008)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      CG14438EP1438 has different effects on different aspects of the Hsap\ATXN182Q.Scer\UAS olivopontocerebellar atrophy model ; the retinal phenotypes are less severe, but the number of nuclear inclusions is exacerbated.

      (Branco et al., 2008)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      sovEP1438, Scer\GAL4GMR.PU is a suppressor of visible | adult stage phenotype of Hsap\ATXN182Q.UAS, Scer\GAL4GMR.PU

      (Branco et al., 2008)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      sovEP1438, Scer\GAL4GMR.PU is an enhancer of retina phenotype of Hsap\HTT128Q.1-336.UAS, Scer\GAL4GMR.PU

      (Branco et al., 2008)
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of CG14438EP1438 enhances the retinal phenotype seen when Hsap\HTT128Q.1-336.Scer\UAS is expressed under the control of Scer\GAL4GMR.PU.

      Expression of CG14438EP1438 suppresses the external eye and retinal phenotypes seen when Hsap\ATXN182Q.Scer\UAS is expressed under the control of Scer\GAL4GMR.PU.

      Expression of CG14438EP1438 increases the number of neurons that contain nuclear inclusions seen when Hsap\ATXN182Q.Scer\UAS is expressed under the control of Scer\GAL4ey-OK107.

      Expression of CG14438EP1438 increases the number of neurons that contain nuclear inclusions seen when Hsap\HTT128Q.1-336.Scer\UAS is expressed under the control of Scer\GAL4ey-OK107.

      (Branco et al., 2008)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG14438EP1438
      sovEP1438
      Name Synonyms
      Secondary FlyBase IDs
        References (2)