FlyBase Allele Report: Dmel\Sod2[KG06854]

General Information

Symbol

Dmel\Sod2^KG06854

Species

D. melanogaster

Name

FlyBase ID

FBal0134151

Feature type

allele

Associated gene

Dmel\Sod2

Associated Insertion(s)

P{SUPor-P}Sod2^KG06854

Carried in Construct

Also Known As

Sod2^wk, KG06854

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Paul et al., 2007)

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{SUPor-P}Sod2^KG06854

Cytology

Description

Insertion in the 5'-untranslated region, 102bp upstream of the translation start site.

(Duttaroy et al., 2003)

Allele components

Component

Use(s)

Inserted element

P{SUPor-P}

insertional mutagenesis tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:16,773,894..16,773,894 [-]

(Paul et al., 2007, Duttaroy et al., 2003, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal smell perception | progressive (with Sod2ⁿ²⁸³)

(Paul et al., 2007)

bang sensitive (with Sod2ⁿ²⁸³)

(Itsara et al., 2014)

fertile

(Duttaroy et al., 2003)

short lived

(Paul et al., 2007)

short lived (with Sod2ⁿ²⁸³)

(Itsara et al., 2014, Paul et al., 2007)

viable

(Duttaroy et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

Both the median and maximum lifespan of Sod2ⁿ²⁸³/Sod2^KG06854 flies are shortened by approximately 30% compared to wild-type controls.

40- to 42-day old Sod2ⁿ²⁸³/Sod2^KG06854 adults show no increase in the mtDNA mutation frequency compared to controls.

(Itsara et al., 2014)

Mean and maximum lifespan are reduced by 20-24% in homozygous flies. The flies show increased age-specific mortality.

Mean and maximum lifespan are reduced by 38% and 43% respectively in Sod2ⁿ²⁸³/Sod2^KG06854 flies. The flies show increased age-specific mortality.

Odor avoidance declines more rapidly with age in Sod2ⁿ²⁸³/Sod2^KG06854 flies than in wild-type controls.

(Paul et al., 2007)

Heterozygotes show normal sensitivity to oxidative stress (treatment with paraquat).

(Duttaroy et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Sod2ⁿ²⁸³/Sod2^KG06854 has bang sensitive phenotype, enhanceable by Ogg1^f08013/Ogg1^f08013

(Itsara et al., 2014)

Sod2ⁿ²⁸³/Sod2^KG06854 has short lived phenotype, enhanceable by Ogg1^f08013/Ogg1^f08013

(Itsara et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

14052

y¹ w^67c23; P{SUPor-P}Sod2^KG06854

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

SOD2^wk

(Vincow et al., 2013)

Sod2^KG06854

Sod2^wk

(Thomas et al., 2018, Itsara et al., 2014, Paul et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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