FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rac1Y40C.UAS.Tag:MYC
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General Information
Symbol
Dmel\Rac1Y40C.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0135832
Feature type
allele
Associated gene
Dmel\Rac1
Associated Insertion(s)
Carried in Construct
P{UAS-Myc-Rac1.Y40C}
Key Links
Transgenic product class
missense_variant
(Ng et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Ng et al., 2002)
Mutagen
in vitro construct
(Ng et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-Myc-Rac1.Y40C}
Cytology
Description

UASt regulatory sequences drive expression of a mutated form of Rac1 (carries the amino acid replacement Y40C) tagged at the N-terminal end with two copies of Tag:MYC.

(Ng et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Rac1
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Rac1Y40C.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4OK107 does not disrupt mushroom body axon patterning in a wild-type background.

      (Ng et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Rac1Y40C.Scer\UAS.T:Hsap\MYC suppresses the axon growth defect and F-actin elevation seen in the α/β mushroom body lobes when LIMK1Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4ey-OK107. This suppression does not occur in a sickΔ/sickA384 mutant background.

      (Abe et al., 2014)

      Mushroom body axon growth defects in single-cell Rac1J11 Rac2Δ MtlΔ γ neuron clones are largely rescued by expression of Rac1Y40C.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4OK107. 81% of axons in Rac1J11 Rac2Δ mushroom body clones show mutant phenotypes, predominantly guidance (55%) and branching (24%) defects. Expression of Rac1Y40C.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4OK107 does not reduce the total percentage of axonal defects, but results in a marked shift in the distribution of defects, with most showing branching (45%) rather than guidance (31%) defects.

      (Ng et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rac1Y40C.Scer\UAS.T:Hsap\MYC
      Rac1Y40C.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (3)