FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PGRP-LCΔ5
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General Information
Symbol
Dmel\PGRP-LCΔ5
Species
D. melanogaster
Name
FlyBase ID
FBal0135887
Feature type
allele
Associated gene
Dmel\PGRP-LC
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Ramet et al., 2002)
Mutagen
P-element activity
(Ramet et al., 2002)
Progenitor genotype
PGRP-LCBG00650
(Ramet et al., 2002)
Cytology
Description

Imprecise excision of the P{GT1} element that removes at least the first exon of PGRP-LC.

(Ramet et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      RelE20 adults show large lipid droplets in the fat body; however, under bacterial infection with heat-killed E.coli, lipid droplets become small.

      (Wang et al., 2021)

      Mutant flies are susceptible to infection by E.coli compared to wild-type flies.

      (Ramet et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      PGRP-LCΔ5 is a suppressor of increased mortality | conditional phenotype of imaΔ

      (Snee et al., 2023)

      PGRP-LCΔ5 is a suppressor of abnormal immune response | adult stage phenotype of imaΔ

      (Snee et al., 2023)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PGRP-LCDelta5
      (Yang et al., 2019)
      PGRP-LCΔ5
      (Snee et al., 2023, Shen et al., 2022, Jugder et al., 2021, Wang et al., 2021, Schmidt et al., 2011)
      PGRP-LCΔ5
      (Kietz et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)