FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Syt1UAS.cMa
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General Information
Symbol
Dmel\Syt1UAS.cMa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Mackler
FlyBase ID
FBal0137072
Feature type
allele
Associated gene
Dmel\Syt1
Associated Insertion(s)
Carried in Construct
P{UAS-syt.M}
Also Known As
P[sytWT]
Key Links
Transgenic product class
wild_type
(Mackler and Reist, 2001)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Mackler and Reist, 2001)
Mutagen
in vitro construct
(Mackler et al., 2002, Mackler and Reist, 2001)
Progenitor genotype
Carried in construct
P{UAS-syt.M}
Cytology
Description

UASt regulatory sequences drive expression of wild-type Syt1.

(Mackler and Reist, 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Syt1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      There is no difference in τ values in Syt1AD4/Syt1N13; Syt1Scer\UAS.cMa Scer\GAL4elav.PLu flies in response to a 50Hz, 10s stimulus.

      (Poskanzer et al., 2006)

      The Ca2+ dependence of neurotransmitter release in larvae expressing sytB-D3.4N.Scer\UAS under the control of Scer\GAL4elav.PLu in a sytAD4 background is significantly shifted compared to the Ca2+ dependence of neurotransmitter release in larvae expressing sytScer\UAS.cMa under the control of Scer\GAL4elav.PLu in a sytAD4 background.

      (Mackler et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Syt1UAS.cMa/Scer\GAL4elav.PLu rescues Syt1AD4/Syt1N13

      (Poskanzer et al., 2006)
      Partially rescues

      Syt1UAS.cMa/Scer\GAL4elav.PLu partially rescues Syt1AD4

      (Mackler and Reist, 2001)
      Comments

      Expression of sytScer\UAS.cMa under the control of Scer\GAL4elav.PLu rescues the lethality of sytAD4 flies; 85 +/- 6% of the expected number survive. The rescued adults are slightly uncoordinated. sytAD4 homozygous larvae which are also expressing sytScer\UAS.cMa under the control of Scer\GAL4elav.PLu have a mean excitatory junction potential (EJP) amplitude at the neuromuscular junction which is 67% of that of control larvae. The frequency of spontaneous miniature EJPs (mEJPs) in these larvae is slightly increased compared to controls (the difference is not statistically significant). The distribution of quantal sizes and the mean quantal size of the mEJPs is not different from controls. The mean excitatory junction potential (EJP) amplitude at the neuromuscular junction of sytAD4 homozygous larvae which are also expressing sytKQ.Scer\UAS under the control of Scer\GAL4elav.PLu is significantly reduced compared to the mean EJP amplitude of sytAD4 homozygous larvae which are also expressing sytScer\UAS.cMa under the control of Scer\GAL4elav.PLu. The mean miniature EJP (mEJP) amplitude at the neuromuscular junction of sytAD4 homozygous larvae which are also expressing sytKQ.Scer\UAS under the control of Scer\GAL4elav.PLu is not significantly different from the mean mEJP amplitude of sytAD4 homozygous larvae which are also expressing sytScer\UAS.cMa under the control of Scer\GAL4elav.PLu. The mean mEJP frequency at the neuromuscular junction of sytAD4 homozygous larvae which are also expressing sytKQ.Scer\UAS under the control of Scer\GAL4elav.PLu is approximately twice that of sytAD4 homozygous larvae which are also expressing sytScer\UAS.cMa under the control of Scer\GAL4elav.PLu.

      (Mackler and Reist, 2001)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Syt1Scer\UAS.cMa
      Syt1UAS.cMa
      sytScer\UAS.cMa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Mackler
      (Mackler and Reist, 2001)
      Secondary FlyBase IDs
        References (6)